Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

Objective: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protei...

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Bibliographic Details
Main Authors: Hyunbae Kim, Juncheng Wei, Zhenfeng Song, Emilio Mottillo, Lobelia Samavati, Ren Zhang, Li Li, Xuequn Chen, Bhanu P. Jena, Jiandie D. Lin, Deyu Fang, Kezhong Zhang
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Molecular Metabolism
Subjects:
Endoplasmic reticulum
ER-associated degradation
Lipid metabolism
Circadian metabolism
Transcriptional regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000326

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