Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis
Abstract Background This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery. Methods Potential studies were identified in the following electronic databases: PubMe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-03-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-018-0747-8 |
| _version_ | 1811306600789442560 |
|---|---|
| author | Ran Ma Guan-Hong Chen Liu-Jing Zhao Xi-Cheng Zhai |
| author_facet | Ran Ma Guan-Hong Chen Liu-Jing Zhao Xi-Cheng Zhai |
| author_sort | Ran Ma |
| collection | DOAJ |
| description | Abstract Background This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery. Methods Potential studies were identified in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Google. We included studies involving hip surgery patients in which the intervention group received naproxen and the control group received placebo. The occurrence of heterotopic ossification and complications were the final outcomes. Stata 13.0 was used for the meta-analysis. Results Four randomized controlled trials (RCTs) involving 269 patients were ultimately included in this meta-analysis. The use of naproxen was associated with a significant reduction in the occurrence of heterotopic ossification at 1.5-, 3-, 6-, and 12-month follow-ups (P < 0.05). There was no significant difference in the occurrence of complications between treatment and control groups (P > 0.05). Conclusion Our analysis indicates that naproxen can decrease the occurrence of heterotopic ossification without increasing complications in hip surgery patients. Due to the limited number of studies included, more high-quality RCTs are needed to identify the optimal dose of naproxen. |
| first_indexed | 2024-04-13T08:48:23Z |
| format | Article |
| id | doaj.art-037641c95900413f9dab574f848fa706 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T08:48:23Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-037641c95900413f9dab574f848fa7062022-12-22T02:53:35ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2018-03-011311810.1186/s13018-018-0747-8Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysisRan Ma0Guan-Hong Chen1Liu-Jing Zhao2Xi-Cheng Zhai3Department of Orthopedics, Shanxian Central HospitalDepartment of Orthopedics, Shanxian Central HospitalDepartment of Orthopedics, Shanxian Central HospitalDepartment of Orthopedics, Shanxian Central HospitalAbstract Background This meta-analysis aimed to assess whether the specific nonsteroidal anti-inflammatory drug (NSAID) naproxen has a role in reducing the occurrence of heterotopic ossification after hip surgery. Methods Potential studies were identified in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Google. We included studies involving hip surgery patients in which the intervention group received naproxen and the control group received placebo. The occurrence of heterotopic ossification and complications were the final outcomes. Stata 13.0 was used for the meta-analysis. Results Four randomized controlled trials (RCTs) involving 269 patients were ultimately included in this meta-analysis. The use of naproxen was associated with a significant reduction in the occurrence of heterotopic ossification at 1.5-, 3-, 6-, and 12-month follow-ups (P < 0.05). There was no significant difference in the occurrence of complications between treatment and control groups (P > 0.05). Conclusion Our analysis indicates that naproxen can decrease the occurrence of heterotopic ossification without increasing complications in hip surgery patients. Due to the limited number of studies included, more high-quality RCTs are needed to identify the optimal dose of naproxen.http://link.springer.com/article/10.1186/s13018-018-0747-8NaproxenHip surgeryHeterotopic ossificationMeta-analysis |
| spellingShingle | Ran Ma Guan-Hong Chen Liu-Jing Zhao Xi-Cheng Zhai Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis Journal of Orthopaedic Surgery and Research Naproxen Hip surgery Heterotopic ossification Meta-analysis |
| title | Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis |
| title_full | Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis |
| title_fullStr | Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis |
| title_full_unstemmed | Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis |
| title_short | Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis |
| title_sort | efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery a meta analysis |
| topic | Naproxen Hip surgery Heterotopic ossification Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13018-018-0747-8 |
| work_keys_str_mv | AT ranma efficacyofnaproxenprophylaxisforthepreventionofheterotopicossificationafterhipsurgeryametaanalysis AT guanhongchen efficacyofnaproxenprophylaxisforthepreventionofheterotopicossificationafterhipsurgeryametaanalysis AT liujingzhao efficacyofnaproxenprophylaxisforthepreventionofheterotopicossificationafterhipsurgeryametaanalysis AT xichengzhai efficacyofnaproxenprophylaxisforthepreventionofheterotopicossificationafterhipsurgeryametaanalysis |