Hematological Composite Scores in Patients with Inflammatory Bowel Disease
The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been identified as potential inflammatory biomarkers. In this work we aimed to analyze whether...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/23/7248 |
| _version_ | 1797399947701649408 |
|---|---|
| author | Marta Carrillo-Palau Belén Vera-Santana Andrea Morant-Domínguez Alejandro Hernández-Camba Laura Ramos Inmaculada Alonso-Abreu Noemi Hernández Álvarez-Buylla Laura Arranz Milagros Vela Manuel Hernández-Guerra Cristina Gómez-Moreno Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_facet | Marta Carrillo-Palau Belén Vera-Santana Andrea Morant-Domínguez Alejandro Hernández-Camba Laura Ramos Inmaculada Alonso-Abreu Noemi Hernández Álvarez-Buylla Laura Arranz Milagros Vela Manuel Hernández-Guerra Cristina Gómez-Moreno Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_sort | Marta Carrillo-Palau |
| collection | DOAJ |
| description | The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been identified as potential inflammatory biomarkers. In this work we aimed to analyze whether the hematological composite scores differ between inflammatory bowel disease (IBD) patients and healthy controls, and if they are related to disease activity. A total of 197 IBD patients—130 Crohn’s (CD) disease and 67 ulcerative colitis (UC)—and 208 age- and sex-matched healthy controls were enrolled. C-reactive protein and fecal calprotectin were assessed. Multivariable linear regression analysis was executed. After adjustment, NLR and PLR, but not SIRI and MLR, were significantly higher in IBD patients compared to controls. C-reactive protein and SIRI and NLR were correlated in IBD patients. However, fecal calprotectin was not related to any of these blood scores. Furthermore, disease activity parameters were not associated with any of the blood composite scores in both CD and UC patients. In conclusion, NLR and PLR, but not SIRI and MLR, are independently higher in IBD patients compared to controls. However, the four hematological scores are not related to disease activity in either CD or UC patients. Based on these results, blood-based inflammatory scores may not serve as subrogated biomarkers of disease activity in IBD. |
| first_indexed | 2024-03-09T01:48:31Z |
| format | Article |
| id | doaj.art-03782080ac494d7ebcdddec5e88f9941 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T01:48:31Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-03782080ac494d7ebcdddec5e88f99412023-12-08T15:18:52ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011223724810.3390/jcm12237248Hematological Composite Scores in Patients with Inflammatory Bowel DiseaseMarta Carrillo-Palau0Belén Vera-Santana1Andrea Morant-Domínguez2Alejandro Hernández-Camba3Laura Ramos4Inmaculada Alonso-Abreu5Noemi Hernández Álvarez-Buylla6Laura Arranz7Milagros Vela8Manuel Hernández-Guerra9Cristina Gómez-Moreno10Miguel Á. González-Gay11Iván Ferraz-Amaro12Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainFundación Jiménez Díaz School of Nursing of Madrid, Autonomous University of Madrid, 28040 Madrid, SpainDivision of Rheumatology, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainThe neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been identified as potential inflammatory biomarkers. In this work we aimed to analyze whether the hematological composite scores differ between inflammatory bowel disease (IBD) patients and healthy controls, and if they are related to disease activity. A total of 197 IBD patients—130 Crohn’s (CD) disease and 67 ulcerative colitis (UC)—and 208 age- and sex-matched healthy controls were enrolled. C-reactive protein and fecal calprotectin were assessed. Multivariable linear regression analysis was executed. After adjustment, NLR and PLR, but not SIRI and MLR, were significantly higher in IBD patients compared to controls. C-reactive protein and SIRI and NLR were correlated in IBD patients. However, fecal calprotectin was not related to any of these blood scores. Furthermore, disease activity parameters were not associated with any of the blood composite scores in both CD and UC patients. In conclusion, NLR and PLR, but not SIRI and MLR, are independently higher in IBD patients compared to controls. However, the four hematological scores are not related to disease activity in either CD or UC patients. Based on these results, blood-based inflammatory scores may not serve as subrogated biomarkers of disease activity in IBD.https://www.mdpi.com/2077-0383/12/23/7248inflammatory bowel diseasesystemic immune-inflammatory indexhematological inflammatory scores |
| spellingShingle | Marta Carrillo-Palau Belén Vera-Santana Andrea Morant-Domínguez Alejandro Hernández-Camba Laura Ramos Inmaculada Alonso-Abreu Noemi Hernández Álvarez-Buylla Laura Arranz Milagros Vela Manuel Hernández-Guerra Cristina Gómez-Moreno Miguel Á. González-Gay Iván Ferraz-Amaro Hematological Composite Scores in Patients with Inflammatory Bowel Disease Journal of Clinical Medicine inflammatory bowel disease systemic immune-inflammatory index hematological inflammatory scores |
| title | Hematological Composite Scores in Patients with Inflammatory Bowel Disease |
| title_full | Hematological Composite Scores in Patients with Inflammatory Bowel Disease |
| title_fullStr | Hematological Composite Scores in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Hematological Composite Scores in Patients with Inflammatory Bowel Disease |
| title_short | Hematological Composite Scores in Patients with Inflammatory Bowel Disease |
| title_sort | hematological composite scores in patients with inflammatory bowel disease |
| topic | inflammatory bowel disease systemic immune-inflammatory index hematological inflammatory scores |
| url | https://www.mdpi.com/2077-0383/12/23/7248 |
| work_keys_str_mv | AT martacarrillopalau hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT belenverasantana hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT andreamorantdominguez hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT alejandrohernandezcamba hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT lauraramos hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT inmaculadaalonsoabreu hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT noemihernandezalvarezbuylla hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT lauraarranz hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT milagrosvela hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT manuelhernandezguerra hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT cristinagomezmoreno hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT miguelagonzalezgay hematologicalcompositescoresinpatientswithinflammatoryboweldisease AT ivanferrazamaro hematologicalcompositescoresinpatientswithinflammatoryboweldisease |