IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period
Introduction: In the pathogenesis of the FMF disease, cytokines play important roles in the inflammation of the serous membranes. This study aims to investigate the relationship between serum levels of IL-1β, IL-18 and caspase-1 with CRP, ESR, fibrinogen and immune response attack/attack-free period...
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| Format: | Article |
| Language: | English |
| Published: |
Rabia Yılmaz
2021-07-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1675737 |
| _version_ | 1797860592332046336 |
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| author | Köksal Deveci Feyzanur Yıldırımtepe Çaldıran Şenol Çitli Ercan Çaçan |
| author_facet | Köksal Deveci Feyzanur Yıldırımtepe Çaldıran Şenol Çitli Ercan Çaçan |
| author_sort | Köksal Deveci |
| collection | DOAJ |
| description | Introduction: In the pathogenesis of the FMF disease, cytokines play important roles in the inflammation of the serous membranes. This study aims to investigate the relationship between serum levels of IL-1β, IL-18 and caspase-1 with CRP, ESR, fibrinogen and immune response attack/attack-free period.
Material and Method: 60 patients diagnosed with FMF according to Tel-Hashomer criteria were divided into two groups as attack and attack-free period. Serum cytokine levels were examined by the ELISA method in 60 patients and 30 HCs, and the relationship between acute phase reactants and immune response was investigated.
Results: A significant increase in serum concentrations of pro-inflammatory cytokines IL-1β (p = 0.001), IL-18 (p = 0.043) and caspase-1 (p = 0.043) was observed in FMF attack patients compared to control.. And also, IL-1β levels were positively correlated with neutrophils, ESR and CRP in FMF attack patients and there was a relationship between disease severity and IL-1β. In FMF attack-free patients, while a trend towards increased serum IL-1β (p=0.075) and IL-18 (p=0.516) levels were noted, it did not reach statistical significance. However, a significant difference was observed in the caspase-1 (p=0.049) levels of attack-free according to HCs.
Conclusion: This study suggests that IL-1β, IL-18 and caspase-1 can serve as a useful marker not only in the attack period but also in the attack-free period, and provide a useful clue for the diagnosis and treatment of the disease. |
| first_indexed | 2024-04-09T21:49:27Z |
| format | Article |
| id | doaj.art-03782e1403114921921a2c84e7c12f26 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:49:27Z |
| publishDate | 2021-07-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-03782e1403114921921a2c84e7c12f262023-03-24T19:43:25ZengRabia YılmazJournal of Contemporary Medicine2667-71802021-07-011144944991809IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free PeriodKöksal Deveci0Feyzanur Yıldırımtepe Çaldıran1Şenol Çitli2Ercan Çaçan3GAZIOSMANPASA UNIVERSITY, FACULTY OF MEDICINETOKAT GAZİOSMANPAŞA ÜNİVERSİTESİRECEP TAYYİP ERDOĞAN ÜNİVERSİTESİTOKAT GAZİOSMANPAŞA ÜNİVERSİTESİIntroduction: In the pathogenesis of the FMF disease, cytokines play important roles in the inflammation of the serous membranes. This study aims to investigate the relationship between serum levels of IL-1β, IL-18 and caspase-1 with CRP, ESR, fibrinogen and immune response attack/attack-free period. Material and Method: 60 patients diagnosed with FMF according to Tel-Hashomer criteria were divided into two groups as attack and attack-free period. Serum cytokine levels were examined by the ELISA method in 60 patients and 30 HCs, and the relationship between acute phase reactants and immune response was investigated. Results: A significant increase in serum concentrations of pro-inflammatory cytokines IL-1β (p = 0.001), IL-18 (p = 0.043) and caspase-1 (p = 0.043) was observed in FMF attack patients compared to control.. And also, IL-1β levels were positively correlated with neutrophils, ESR and CRP in FMF attack patients and there was a relationship between disease severity and IL-1β. In FMF attack-free patients, while a trend towards increased serum IL-1β (p=0.075) and IL-18 (p=0.516) levels were noted, it did not reach statistical significance. However, a significant difference was observed in the caspase-1 (p=0.049) levels of attack-free according to HCs. Conclusion: This study suggests that IL-1β, IL-18 and caspase-1 can serve as a useful marker not only in the attack period but also in the attack-free period, and provide a useful clue for the diagnosis and treatment of the disease.https://dergipark.org.tr/tr/download/article-file/1675737autoinflammatory diseasesfamilial mediterranean feverpro-inflammatory cytokinescaspase-1otoinflamatuar hastalıklarailevi akdeniz ateşipro-inflamatuar sitokinlerkazpaz-1 |
| spellingShingle | Köksal Deveci Feyzanur Yıldırımtepe Çaldıran Şenol Çitli Ercan Çaçan IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period Journal of Contemporary Medicine autoinflammatory diseases familial mediterranean fever pro-inflammatory cytokines caspase-1 otoinflamatuar hastalıklar ailevi akdeniz ateşi pro-inflamatuar sitokinler kazpaz-1 |
| title | IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period |
| title_full | IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period |
| title_fullStr | IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period |
| title_full_unstemmed | IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period |
| title_short | IL-1β, IL-18 and Caspase-1 Levels in Serum as an Early Marker in Familial Mediterranean Fever Patients with Attack and Attack-free Period |
| title_sort | il 1β il 18 and caspase 1 levels in serum as an early marker in familial mediterranean fever patients with attack and attack free period |
| topic | autoinflammatory diseases familial mediterranean fever pro-inflammatory cytokines caspase-1 otoinflamatuar hastalıklar ailevi akdeniz ateşi pro-inflamatuar sitokinler kazpaz-1 |
| url | https://dergipark.org.tr/tr/download/article-file/1675737 |
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