Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study
Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is importa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.999701/full |
| _version_ | 1811237414581043200 |
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| author | Zuzana Rennerova Leandro Picó Sirvent Leandro Picó Sirvent Eva Carvajal Roca Eva Carvajal Roca Jarosław Paśnik Mateja Logar Mateja Logar Katarina Milošević Katarina Milošević Juraj Majtan Juraj Majtan Milos Jesenak Milos Jesenak |
| author_facet | Zuzana Rennerova Leandro Picó Sirvent Leandro Picó Sirvent Eva Carvajal Roca Eva Carvajal Roca Jarosław Paśnik Mateja Logar Mateja Logar Katarina Milošević Katarina Milošević Juraj Majtan Juraj Majtan Milos Jesenak Milos Jesenak |
| author_sort | Zuzana Rennerova |
| collection | DOAJ |
| description | Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population. |
| first_indexed | 2024-04-12T12:23:54Z |
| format | Article |
| id | doaj.art-0379532507214beb8f523d938c8fbec1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T12:23:54Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-0379532507214beb8f523d938c8fbec12022-12-22T03:33:13ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-10-011010.3389/fped.2022.999701999701Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective studyZuzana Rennerova0Leandro Picó Sirvent1Leandro Picó Sirvent2Eva Carvajal Roca3Eva Carvajal Roca4Jarosław Paśnik5Mateja Logar6Mateja Logar7Katarina Milošević8Katarina Milošević9Juraj Majtan10Juraj Majtan11Milos Jesenak12Milos Jesenak13Department of Paediatric Pulmonology and Phthisiology, Faculty of Medicine, Slovak Medical University, National Children Institute of Health, Bratislava, SlovakiaPaediatrics Department, Hospital de la Salud, Valencia,SpainFaculty of Medicine and Health Sciences, Valencia Catholic University Saint Vincent Martyr, Valencia, SpainPaediatrics Department, Hospital de la Salud, Valencia,SpainFaculty of Medicine and Health Sciences, Valencia Catholic University Saint Vincent Martyr, Valencia, SpainSalve Medica Warszawa, Warsaw, PolandDepartment of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, SloveniaDepartment of Infectious Diseases and Epidemiology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Pulmonology and Allergology, University Children’s Hospital, Belgrade, SerbiaSchool of Medicine, University of Belgrade, Belgrade, SerbiaInstitute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia0Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia1Department of Paediatrics, Jessenius Faculty of Medicine, University Teaching Hospital in Martin, Comenius University in Bratislava, Martin, Slovakia2Department of Clinical Immunology and Allergology, University Teaching Hospital in Martin, Martin, SlovakiaPreschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population.https://www.frontiersin.org/articles/10.3389/fped.2022.999701/fullpleuranrespiratory tract infectionsbeta-glucanchildrentolerability |
| spellingShingle | Zuzana Rennerova Leandro Picó Sirvent Leandro Picó Sirvent Eva Carvajal Roca Eva Carvajal Roca Jarosław Paśnik Mateja Logar Mateja Logar Katarina Milošević Katarina Milošević Juraj Majtan Juraj Majtan Milos Jesenak Milos Jesenak Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study Frontiers in Pediatrics pleuran respiratory tract infections beta-glucan children tolerability |
| title | Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study |
| title_full | Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study |
| title_fullStr | Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study |
| title_full_unstemmed | Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study |
| title_short | Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study |
| title_sort | beta 1 3 1 6 d glucan from pleurotus ostreatus in the prevention of recurrent respiratory tract infections an international multicentre open label prospective study |
| topic | pleuran respiratory tract infections beta-glucan children tolerability |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.999701/full |
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