Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study
Introduction: In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of muscle and bone density. Vitamin D is associated with the growth and function of muscle tissue thro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Clinical & Translational Endocrinology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623723000121 |
| _version_ | 1797398539853103104 |
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| author | Luiz Phellipe Dell Aquila Armando Morales Patricia Moreira Maysa Seabra Cendoroglo Rosilene Motta Elias Maria Aparecida Dalboni |
| author_facet | Luiz Phellipe Dell Aquila Armando Morales Patricia Moreira Maysa Seabra Cendoroglo Rosilene Motta Elias Maria Aparecida Dalboni |
| author_sort | Luiz Phellipe Dell Aquila |
| collection | DOAJ |
| description | Introduction: In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of muscle and bone density. Vitamin D is associated with the growth and function of muscle tissue through interactions between the vitamin D receptor and PGC-1α and activation of p38/MAPK (mitogen-activated protein kinase) in muscle, a mechanism similar to irisin action. The aim of this pilot study was to evaluate the effects of cholecalciferol supplementation on serum irisin levels in sedentary postmenopausal women with hypovitaminosis D (25(OH)D < 20 ng/mL). Material and methods: 80 sedentary postmenopausal women with hypovitaminosis D and low sun exposure were supplemented with cholecalciferol (30,000 IU/month) for 12 months. Calcium, parathyroid hormone, alkaline phosphatase (AP) and irisin levels were measured before and after supplementation. Results: 25(OH) vitamin D increased in all participants. Serum levels of irisin increased (from 0.52 ± 0.27 to 0.80 ± 0.53; p < 0.003), accompanied by a decrease in AP (from 80 ± 24 to 66 ± 23; p < 0.001). Conclusions: Restoration of vitamin D status increased serum irisin levels in sedentary postmenopausal women. Whether increased serum irisin levels may have an impact on clinical outcomes deserves further evaluation. |
| first_indexed | 2024-03-09T01:26:57Z |
| format | Article |
| id | doaj.art-037ca4701970412e9aaa63abc1c633bc |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-03-09T01:26:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-037ca4701970412e9aaa63abc1c633bc2023-12-10T06:16:10ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372023-12-0134100324Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot studyLuiz Phellipe Dell Aquila0Armando Morales1Patricia Moreira2Maysa Seabra Cendoroglo3Rosilene Motta Elias4Maria Aparecida Dalboni5Universidade Nove de Julho (UNINOVE), São Paulo, BrazilUniversidade Nove de Julho (UNINOVE), São Paulo, BrazilUniversidade Federal de São Paulo (UNIFEP), São Paulo, BrazilUniversidade Federal de São Paulo (UNIFEP), São Paulo, BrazilUniversidade Nove de Julho (UNINOVE), São Paulo, BrazilUniversidade Nove de Julho (UNINOVE), São Paulo, Brazil; Corresponding author at: Universidade Nove de Julho – UNINOVE, São Paulo, SP, Brazil.Introduction: In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of muscle and bone density. Vitamin D is associated with the growth and function of muscle tissue through interactions between the vitamin D receptor and PGC-1α and activation of p38/MAPK (mitogen-activated protein kinase) in muscle, a mechanism similar to irisin action. The aim of this pilot study was to evaluate the effects of cholecalciferol supplementation on serum irisin levels in sedentary postmenopausal women with hypovitaminosis D (25(OH)D < 20 ng/mL). Material and methods: 80 sedentary postmenopausal women with hypovitaminosis D and low sun exposure were supplemented with cholecalciferol (30,000 IU/month) for 12 months. Calcium, parathyroid hormone, alkaline phosphatase (AP) and irisin levels were measured before and after supplementation. Results: 25(OH) vitamin D increased in all participants. Serum levels of irisin increased (from 0.52 ± 0.27 to 0.80 ± 0.53; p < 0.003), accompanied by a decrease in AP (from 80 ± 24 to 66 ± 23; p < 0.001). Conclusions: Restoration of vitamin D status increased serum irisin levels in sedentary postmenopausal women. Whether increased serum irisin levels may have an impact on clinical outcomes deserves further evaluation.http://www.sciencedirect.com/science/article/pii/S2214623723000121Vitamin DPost-menopausal womenIrisin |
| spellingShingle | Luiz Phellipe Dell Aquila Armando Morales Patricia Moreira Maysa Seabra Cendoroglo Rosilene Motta Elias Maria Aparecida Dalboni Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study Journal of Clinical & Translational Endocrinology Vitamin D Post-menopausal women Irisin |
| title | Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study |
| title_full | Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study |
| title_fullStr | Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study |
| title_full_unstemmed | Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study |
| title_short | Prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women: A pilot study |
| title_sort | prospective effects of cholecalciferol supplementation on irisin levels in sedentary postmenopausal women a pilot study |
| topic | Vitamin D Post-menopausal women Irisin |
| url | http://www.sciencedirect.com/science/article/pii/S2214623723000121 |
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