Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC

Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC

Summary Dgp71WD/Nedd1 proteins are essential for mitotic spindle formation. In human cells, Nedd1 targets γ-tubulin to both centrosomes and spindles, but in other organisms the function of Dgp71WD/Nedd1 is less clear. In Drosophila cells, Dgp71WD plays a major part in targeting γ-tubulin to spindles...

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Bibliographic Details
Main Authors: Richard F. Reschen, Nathalie Colombie, Lucy Wheatley, Jeroen Dobbelaere, Daniel St Johnston, Hiro Ohkura, Jordan W. Raff
Format: Article
Language:English
Published: The Company of Biologists 2012-03-01
Series:Biology Open
Subjects:
Dgp71WD
Centrosome
Mitosis
Meiosis
Online Access:http://bio.biologists.org/content/1/5/422

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