Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template
Abstract Background For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-p...
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-018-0959-4 |
| _version_ | 1828355749232771072 |
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| author | Yuliang Jiang Zhe Ji Fuxin Guo Ran Peng Haitao Sun Jinghong Fan Shuhua Wei Weiyan Li Kai Liu Jinghua Lei Junjie Wang |
| author_facet | Yuliang Jiang Zhe Ji Fuxin Guo Ran Peng Haitao Sun Jinghong Fan Shuhua Wei Weiyan Li Kai Liu Jinghua Lei Junjie Wang |
| author_sort | Yuliang Jiang |
| collection | DOAJ |
| description | Abstract Background For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D–PNCT) for computed tomography (CT)-guided radioactive 125I seed (RIS) implantation in recurrent cancer of the head and neck. Methods Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D–PNCT-assisted RIS implantation. The prescribed dose was 110–160 Gy. Preoperative planning design, production of individual guide plates, RIS implantation, postoperative dose evaluation, and follow-up were completed for all patients. Side effects in the skin, mucous membranes, blood and spinal cord were evaluated. Results All patients underwent surgery successfully. Duration of follow-up was 4–14 (median, of 8.5) months. The activity of a single RIS was 0.34–0.7 (median, 0.6) mCi. The number of RIS was 10–126 (median, 34). The number of implantation needles was 4–31 (median, 11). The mean D2cc (dose to the most exposed 2-cc volume) and D0.1cc (dose to the most exposed 0.1-cc volume) of the skin were 24.9 (7.1–85.5) and 47.5 (9.4–167.2), respectively, whereas those of the spinal cord were 8.4 (4.5–33.3) and 14.2 (13.6–63.0), mucosa were 35.1 (4.2–82.8) and 87.0 (6.6–214.1), parotid glands were 16.2 (12.8–19.7) and 29.8 (26.1–33.4) and those of the trachea were 17.9 (2.5–45.9) and 32.7 (3.9–83.9), respectively. No case had an acute reaction of grade ≥ 3. Three cases had a grade-1 skin reaction. Blood toxicity did not occur, nor spinal-cord injury. Xerostomia was not aggravated than that of before brachytherapy. One case had a grade-3 nerve response. Conclusions 3D–PNCT-assisted RIS implantation can provide good accuracy for positioning. For local recurrent malignant tumor of head and neck, there were no obvious adverse reactions. |
| first_indexed | 2024-04-14T02:47:33Z |
| format | Article |
| id | doaj.art-037ddb4cfb3f4b5986f8e0ccace433df |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-14T02:47:33Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-037ddb4cfb3f4b5986f8e0ccace433df2022-12-22T02:16:27ZengBMCRadiation Oncology1748-717X2018-02-011311710.1186/s13014-018-0959-4Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar templateYuliang Jiang0Zhe Ji1Fuxin Guo2Ran Peng3Haitao Sun4Jinghong Fan5Shuhua Wei6Weiyan Li7Kai Liu8Jinghua Lei9Junjie Wang10Department of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Radiation Oncology, Peking University Third HospitalDepartment of Oncology, Dingzhou City People’s HospitalDepartment of Oncology, Shiyan City People’s HospitalDepartment of Radiation Oncology, Peking University Third HospitalAbstract Background For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D–PNCT) for computed tomography (CT)-guided radioactive 125I seed (RIS) implantation in recurrent cancer of the head and neck. Methods Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D–PNCT-assisted RIS implantation. The prescribed dose was 110–160 Gy. Preoperative planning design, production of individual guide plates, RIS implantation, postoperative dose evaluation, and follow-up were completed for all patients. Side effects in the skin, mucous membranes, blood and spinal cord were evaluated. Results All patients underwent surgery successfully. Duration of follow-up was 4–14 (median, of 8.5) months. The activity of a single RIS was 0.34–0.7 (median, 0.6) mCi. The number of RIS was 10–126 (median, 34). The number of implantation needles was 4–31 (median, 11). The mean D2cc (dose to the most exposed 2-cc volume) and D0.1cc (dose to the most exposed 0.1-cc volume) of the skin were 24.9 (7.1–85.5) and 47.5 (9.4–167.2), respectively, whereas those of the spinal cord were 8.4 (4.5–33.3) and 14.2 (13.6–63.0), mucosa were 35.1 (4.2–82.8) and 87.0 (6.6–214.1), parotid glands were 16.2 (12.8–19.7) and 29.8 (26.1–33.4) and those of the trachea were 17.9 (2.5–45.9) and 32.7 (3.9–83.9), respectively. No case had an acute reaction of grade ≥ 3. Three cases had a grade-1 skin reaction. Blood toxicity did not occur, nor spinal-cord injury. Xerostomia was not aggravated than that of before brachytherapy. One case had a grade-3 nerve response. Conclusions 3D–PNCT-assisted RIS implantation can provide good accuracy for positioning. For local recurrent malignant tumor of head and neck, there were no obvious adverse reactions.http://link.springer.com/article/10.1186/s13014-018-0959-43D printing non co-planar template125I seed implantationSide effectHead and neck carcinoma |
| spellingShingle | Yuliang Jiang Zhe Ji Fuxin Guo Ran Peng Haitao Sun Jinghong Fan Shuhua Wei Weiyan Li Kai Liu Jinghua Lei Junjie Wang Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template Radiation Oncology 3D printing non co-planar template 125I seed implantation Side effect Head and neck carcinoma |
| title | Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template |
| title_full | Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template |
| title_fullStr | Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template |
| title_full_unstemmed | Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template |
| title_short | Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template |
| title_sort | side effects of ct guided implantation of 125i seeds for recurrent malignant tumors of the head and neck assisted by 3d printing non co planar template |
| topic | 3D printing non co-planar template 125I seed implantation Side effect Head and neck carcinoma |
| url | http://link.springer.com/article/10.1186/s13014-018-0959-4 |
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