Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge
Crimean–Congo hemorrhagic fever virus (CCHFV) infection is identified in the 2018 World Health Organization Research and Development Blueprint and the National Institute of Allergy and Infectious Diseases (NIH/NIAID) priority A list due to its high risk to public health and national security. Tick-b...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/5/3/113 |
| _version_ | 1797563123827212288 |
|---|---|
| author | Teresa E. Sorvillo Sergio E. Rodriguez Peter Hudson Megan Carey Luis L. Rodriguez Christina F. Spiropoulou Brian H. Bird Jessica R. Spengler Dennis A. Bente |
| author_facet | Teresa E. Sorvillo Sergio E. Rodriguez Peter Hudson Megan Carey Luis L. Rodriguez Christina F. Spiropoulou Brian H. Bird Jessica R. Spengler Dennis A. Bente |
| author_sort | Teresa E. Sorvillo |
| collection | DOAJ |
| description | Crimean–Congo hemorrhagic fever virus (CCHFV) infection is identified in the 2018 World Health Organization Research and Development Blueprint and the National Institute of Allergy and Infectious Diseases (NIH/NIAID) priority A list due to its high risk to public health and national security. Tick-borne CCHFV is widespread, found in Europe, Asia, Africa, the Middle East, and the Indian subcontinent. It circulates between ticks and several vertebrate hosts without causing overt disease, and thus can be present in areas without being noticed by the public. As a result, the potential for zoonotic spillover from ticks and animals to humans is high. In contrast to other emerging viruses, human-to-human transmission of CCHFV is typically limited; therefore, prevention of spillover events should be prioritized when considering countermeasures. Several factors in the transmission dynamics of CCHFV, including a complex transmission cycle that involves both ticks and vertebrate hosts, lend themselves to a One Health approach for the prevention and control of the disease that are often overlooked by current strategies. Here, we examine critical focus areas to help mitigate CCHFV spillover, including surveillance, risk assessment, and risk reduction strategies concentrated on humans, animals, and ticks; highlight gaps in knowledge; and discuss considerations for a more sustainable One Health approach to disease control. |
| first_indexed | 2024-03-10T18:38:09Z |
| format | Article |
| id | doaj.art-037ddeb6444b4f97846115b1d8797fdc |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T18:38:09Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-037ddeb6444b4f97846115b1d8797fdc2023-11-20T06:02:59ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-07-015311310.3390/tropicalmed5030113Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in KnowledgeTeresa E. Sorvillo0Sergio E. Rodriguez1Peter Hudson2Megan Carey3Luis L. Rodriguez4Christina F. Spiropoulou5Brian H. Bird6Jessica R. Spengler7Dennis A. Bente8One Health Institute, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAHuck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAForeign Animal Disease Research Unit, Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Orient Point, NY 11957, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAOne Health Institute, School of Veterinary Medicine, University of California Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USAViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USACrimean–Congo hemorrhagic fever virus (CCHFV) infection is identified in the 2018 World Health Organization Research and Development Blueprint and the National Institute of Allergy and Infectious Diseases (NIH/NIAID) priority A list due to its high risk to public health and national security. Tick-borne CCHFV is widespread, found in Europe, Asia, Africa, the Middle East, and the Indian subcontinent. It circulates between ticks and several vertebrate hosts without causing overt disease, and thus can be present in areas without being noticed by the public. As a result, the potential for zoonotic spillover from ticks and animals to humans is high. In contrast to other emerging viruses, human-to-human transmission of CCHFV is typically limited; therefore, prevention of spillover events should be prioritized when considering countermeasures. Several factors in the transmission dynamics of CCHFV, including a complex transmission cycle that involves both ticks and vertebrate hosts, lend themselves to a One Health approach for the prevention and control of the disease that are often overlooked by current strategies. Here, we examine critical focus areas to help mitigate CCHFV spillover, including surveillance, risk assessment, and risk reduction strategies concentrated on humans, animals, and ticks; highlight gaps in knowledge; and discuss considerations for a more sustainable One Health approach to disease control.https://www.mdpi.com/2414-6366/5/3/113One Healthspilloveranimal-human interfaceCrimean–Congo hemorrhagic fevertick-borne virusoutbreak response |
| spellingShingle | Teresa E. Sorvillo Sergio E. Rodriguez Peter Hudson Megan Carey Luis L. Rodriguez Christina F. Spiropoulou Brian H. Bird Jessica R. Spengler Dennis A. Bente Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge Tropical Medicine and Infectious Disease One Health spillover animal-human interface Crimean–Congo hemorrhagic fever tick-borne virus outbreak response |
| title | Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge |
| title_full | Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge |
| title_fullStr | Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge |
| title_full_unstemmed | Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge |
| title_short | Towards a Sustainable One Health Approach to Crimean–Congo Hemorrhagic Fever Prevention: Focus Areas and Gaps in Knowledge |
| title_sort | towards a sustainable one health approach to crimean congo hemorrhagic fever prevention focus areas and gaps in knowledge |
| topic | One Health spillover animal-human interface Crimean–Congo hemorrhagic fever tick-borne virus outbreak response |
| url | https://www.mdpi.com/2414-6366/5/3/113 |
| work_keys_str_mv | AT teresaesorvillo towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT sergioerodriguez towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT peterhudson towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT megancarey towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT luislrodriguez towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT christinafspiropoulou towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT brianhbird towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT jessicarspengler towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge AT dennisabente towardsasustainableonehealthapproachtocrimeancongohemorrhagicfeverpreventionfocusareasandgapsinknowledge |