Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease
Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide. In this paper, we investigated the preventive effect of polysaccharide peptide (PSP), isolated from JNPF-CV05 strain of Coriolus versicolor, on alcohol-induced liver injury in mice. Our data demonstrat...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617307235 |
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| author | Yilin Ren Yan Geng Hedi Chen Zhen-Ming Lu Jin-Song Shi Zhenghong Xu |
| author_facet | Yilin Ren Yan Geng Hedi Chen Zhen-Ming Lu Jin-Song Shi Zhenghong Xu |
| author_sort | Yilin Ren |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide. In this paper, we investigated the preventive effect of polysaccharide peptide (PSP), isolated from JNPF-CV05 strain of Coriolus versicolor, on alcohol-induced liver injury in mice. Our data demonstrated that PSP supplementation attenuated ethanol-induced aspartate transaminase (ALT), aspartate transaminase (AST), and microscale malondialdehyde (MDA). Pre-treatment with PSP also significantly decreased ethanol-induced plasma levels of total cholesterol (TC), triacylglycerol (TG), and endotoxin concentration. Mechanistically, PSP treatment upregulated ethanol stimulated the hepatic expression of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC) and peroxisome proliferator–activated receptor α (PPARα) to inhibit hepatic lipid accumulation. In addition, PSP markedly reduced ethanol stimulated inflammation via inhibiting Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) mediated nuclear transcription factor- kappa B (NF-κB) signaling pathway. In conclusion, PSP is effective in ameliorating ethanol-induced hepatic steatosis and injury through reducing lipid accumulation during the development of fatty liver and alleviating endotoxin-mediated inflammation. Our findings strengthen that PSP has potential as a dietary supplement or prescription for ALD. |
| first_indexed | 2024-12-20T11:11:42Z |
| format | Article |
| id | doaj.art-037eac60d380493ba6cdbc07be105981 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T11:11:42Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-037eac60d380493ba6cdbc07be1059812022-12-21T19:42:44ZengElsevierJournal of Functional Foods1756-46462018-01-0140769777Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver diseaseYilin Ren0Yan Geng1Hedi Chen2Zhen-Ming Lu3Jin-Song Shi4Zhenghong Xu5The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, PR ChinaSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR ChinaSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR ChinaThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, PR ChinaSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR ChinaThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, PR China; Corresponding author at: School of Biotechnology, Jiangnan University, Wuxi, PR China.Alcoholic liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide. In this paper, we investigated the preventive effect of polysaccharide peptide (PSP), isolated from JNPF-CV05 strain of Coriolus versicolor, on alcohol-induced liver injury in mice. Our data demonstrated that PSP supplementation attenuated ethanol-induced aspartate transaminase (ALT), aspartate transaminase (AST), and microscale malondialdehyde (MDA). Pre-treatment with PSP also significantly decreased ethanol-induced plasma levels of total cholesterol (TC), triacylglycerol (TG), and endotoxin concentration. Mechanistically, PSP treatment upregulated ethanol stimulated the hepatic expression of AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC) and peroxisome proliferator–activated receptor α (PPARα) to inhibit hepatic lipid accumulation. In addition, PSP markedly reduced ethanol stimulated inflammation via inhibiting Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) mediated nuclear transcription factor- kappa B (NF-κB) signaling pathway. In conclusion, PSP is effective in ameliorating ethanol-induced hepatic steatosis and injury through reducing lipid accumulation during the development of fatty liver and alleviating endotoxin-mediated inflammation. Our findings strengthen that PSP has potential as a dietary supplement or prescription for ALD.http://www.sciencedirect.com/science/article/pii/S1756464617307235Polysaccharide peptides from Coriolus versicolorAlcoholic liver diseaseSteatosisAMPKInflammation |
| spellingShingle | Yilin Ren Yan Geng Hedi Chen Zhen-Ming Lu Jin-Song Shi Zhenghong Xu Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease Journal of Functional Foods Polysaccharide peptides from Coriolus versicolor Alcoholic liver disease Steatosis AMPK Inflammation |
| title | Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease |
| title_full | Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease |
| title_fullStr | Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease |
| title_full_unstemmed | Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease |
| title_short | Polysaccharide peptides from Coriolus versicolor: A multi-targeted approach for the protection or prevention of alcoholic liver disease |
| title_sort | polysaccharide peptides from coriolus versicolor a multi targeted approach for the protection or prevention of alcoholic liver disease |
| topic | Polysaccharide peptides from Coriolus versicolor Alcoholic liver disease Steatosis AMPK Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617307235 |
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