Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter

Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter

Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous compounds and is abundantly expressed in the liver, kidneys, and intestines. The high amino acid similarity between human and porcine CYP1A1 ind...

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Bibliographic Details
Main Authors: Xuan Xie, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng, Jikai Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
porcine
CYP1A1
Sp1
AhR
basal transactivation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00927/full

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