HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets
As part of their life-cycle, malaria parasites undergo rapid cell multiplication and division, with one parasite giving rise to over 20 new parasites within the course of 48 h. To support this, the parasite has an extremely high metabolic rate and level of protein biosynthesis. Underpinning these ac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.968248/full |
| _version_ | 1828517806614773760 |
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| author | Julian Barth Tim Schach Jude M. Przyborski |
| author_facet | Julian Barth Tim Schach Jude M. Przyborski |
| author_sort | Julian Barth |
| collection | DOAJ |
| description | As part of their life-cycle, malaria parasites undergo rapid cell multiplication and division, with one parasite giving rise to over 20 new parasites within the course of 48 h. To support this, the parasite has an extremely high metabolic rate and level of protein biosynthesis. Underpinning these activities, the parasite encodes a number of chaperone/heat shock proteins, belonging to various families. Research over the past decade has revealed that these proteins are involved in a number of essential processes within the parasite, or within the infected host cell. Due to this, these proteins are now being viewed as potential targets for drug development, and we have begun to characterize their properties in more detail. In this article we summarize the current state of knowledge about one particular chaperone family, that of the HSP70, and highlight their importance, function, and potential co-chaperone interactions. This is then discussed with regard to the suitability of these proteins and interactions for drug development. |
| first_indexed | 2024-12-11T18:46:31Z |
| format | Article |
| id | doaj.art-037fe3037bb84b988283d8fc2524e96f |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-11T18:46:31Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-037fe3037bb84b988283d8fc2524e96f2022-12-22T00:54:26ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-08-01910.3389/fmolb.2022.968248968248HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targetsJulian BarthTim SchachJude M. PrzyborskiAs part of their life-cycle, malaria parasites undergo rapid cell multiplication and division, with one parasite giving rise to over 20 new parasites within the course of 48 h. To support this, the parasite has an extremely high metabolic rate and level of protein biosynthesis. Underpinning these activities, the parasite encodes a number of chaperone/heat shock proteins, belonging to various families. Research over the past decade has revealed that these proteins are involved in a number of essential processes within the parasite, or within the infected host cell. Due to this, these proteins are now being viewed as potential targets for drug development, and we have begun to characterize their properties in more detail. In this article we summarize the current state of knowledge about one particular chaperone family, that of the HSP70, and highlight their importance, function, and potential co-chaperone interactions. This is then discussed with regard to the suitability of these proteins and interactions for drug development.https://www.frontiersin.org/articles/10.3389/fmolb.2022.968248/fullchaperonesmalariaPlasmodium falciparumHsp40Hsp70protein-protein interaction |
| spellingShingle | Julian Barth Tim Schach Jude M. Przyborski HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets Frontiers in Molecular Biosciences chaperones malaria Plasmodium falciparum Hsp40 Hsp70 protein-protein interaction |
| title | HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets |
| title_full | HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets |
| title_fullStr | HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets |
| title_full_unstemmed | HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets |
| title_short | HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets |
| title_sort | hsp70 and their co chaperones in the human malaria parasite p falciparum and their potential as drug targets |
| topic | chaperones malaria Plasmodium falciparum Hsp40 Hsp70 protein-protein interaction |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.968248/full |
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