A novel T-cell exhaustion-related feature can accurately predict the prognosis of OC patients

A novel T-cell exhaustion-related feature can accurately predict the prognosis of OC patients

The phenomenon of T Cell exhaustion (TEX) entails a progressive deterioration in the functionality of T cells within the immune system during prolonged conflicts with chronic infections or tumors. In the context of ovarian cancer immunotherapy, the development, and outcome of treatment are closely l...

Full description

Bibliographic Details
Main Authors:	Kemiao Yuan, Songyun Zhao, Bicheng Ye, Qi Wang, Yuan Liu, Pengpeng Zhang, Jiaheng Xie, Hao Chi, Yu Chen, Chao Cheng, Jinhui Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Pharmacology
Subjects:	t cell exhaustion OC ScRNA-seq machine learning immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1192777/full

Similar Items

Editorial: Immune cell exhaustion: new challenges and opportunities in cancer therapy
by: Hao Chi, et al.
Published: (2024-12-01)

Identification of a novel signature based on macrophage-related marker genes to predict prognosis and immunotherapeutic effects in hepatocellular carcinoma
by: Yuanshuai Su, et al.
Published: (2023-05-01)

Combining single-cell sequencing and spatial transcriptome sequencing to identify exosome-related features of glioblastoma and constructing a prognostic model to identify BARD1 as a potential therapeutic target for GBM patients
by: Songyun Zhao, et al.
Published: (2023-08-01)

Identification of peripheral blood immune infiltration signatures and construction of monocyte-associated signatures in ovarian cancer and Alzheimer's disease using single-cell sequencing
by: Songyun Zhao, et al.
Published: (2023-07-01)

Glycosylphosphatidylinositol anchor biosynthesis pathway-based biomarker identification with machine learning for prognosis and T cell exhaustion status prediction in breast cancer
by: Haodong Wu, et al.
Published: (2024-07-01)

Integrated single-cell and bulk RNA-sequencing data reveal molecular subtypes based on lactylation-related genes and prognosis and therapeutic response in glioma
by: Xiangdong Lu, et al.
Published: (2024-05-01)

A novel enterocyte-related 4-gene signature for predicting prognosis in colon adenocarcinoma
by: Xuehua Cheng, et al.
Published: (2022-12-01)

Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing
by: Songyun Zhao, et al.
Published: (2022-12-01)

scCGImpute: An Imputation Method for Single-Cell RNA Sequencing Data Based on Similarities between Cells and Relationships among Genes
by: Tiantian Liu, et al.
Published: (2023-07-01)

scEFSC: Accurate single-cell RNA-seq data analysis via ensemble consensus clustering based on multiple feature selections
by: Chuang Bian, et al.
Published: (2022-01-01)

Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA
by: Weijie Sun, et al.
Published: (2023-05-01)

Identification and validation of a muscle failure index to predict prognosis and immunotherapy in lung adenocarcinoma through integrated analysis of bulk and single-cell RNA sequencing data
by: Xuyu Gu, et al.
Published: (2023-01-01)

Insights gained from single-cell RNA analysis of murine endothelial cells in aging hearts
by: Zhong Liu, et al.
Published: (2023-08-01)

Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy
by: Qiang Su, et al.
Published: (2024-04-01)

New techniques: a roadmap for the development of HCC immunotherapy
by: Dizhi Jiang, et al.
Published: (2023-06-01)

scBubbletree: computational approach for visualization of single cell RNA-seq data
by: Simo Kitanovski, et al.
Published: (2024-09-01)

Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
by: Jiangpeng Wu, et al.
Published: (2023-02-01)

ENGEP: advancing spatial transcriptomics with accurate unmeasured gene expression prediction
by: Shi-Tong Yang, et al.
Published: (2023-12-01)

Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing
by: Aidan S. Marshall, et al.
Published: (2021-06-01)

The Transcriptional Cell Atlas of Testis Development in Sheep at Pre-Sexual Maturity
by: Yi Wu, et al.
Published: (2022-01-01)

B-cell signatures characterize the immune landscape and predict LUAD prognosis via the integration of scRNA-seq and bulk RNA-seq
by: Kexin Xu, et al.
Published: (2025-02-01)

Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
by: Huimeng Yan, et al.
Published: (2024-03-01)

Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq
by: Puxing He, et al.
Published: (2023-06-01)

Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma
by: Tianyu Fan, et al.
Published: (2022-11-01)

Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer
by: Xiaoyu Qin, et al.
Published: (2025-02-01)

High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling
by: Peibo Xu, et al.
Published: (2024-02-01)

Methods, Challenges and Potentials of Single Cell RNA-seq
by: Daniel Hebenstreit
Published: (2012-11-01)

Single‐cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis‐induced liver injury
by: Qian Zhang, et al.
Published: (2023-10-01)

Single-cell transcriptomics identifies the common perturbations of monocyte/macrophage lineage cells in inflammaging of bone marrow
by: Peng Liao, et al.
Published: (2025-01-01)

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery
by: Yang‐Yang Wang, et al.
Published: (2022-01-01)

CAraCAl: CAMML with the integration of chromatin accessibility
by: Courtney Schiebout, et al.
Published: (2024-06-01)

Evaluating imputation methods for single-cell RNA-seq data
by: Yi Cheng, et al.
Published: (2023-07-01)

Integrative single-cell RNA-seq and ATAC-seq analysis of myogenic differentiation in pig
by: Shufang Cai, et al.
Published: (2023-02-01)

Integrating Single-cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancer
by: Jianyu Pang, et al.
Published: (2022-11-01)

Identification of a pro-protein synthesis osteosarcoma subtype for predicting prognosis and treatment
by: Chengfeng Yi, et al.
Published: (2024-07-01)

Metastasis and basement membrane-related signature enhances hepatocellular carcinoma prognosis and diagnosis by integrating single-cell RNA sequencing analysis and immune microenvironment assessment
by: Shijia Wei, et al.
Published: (2024-07-01)

DeepDecon accurately estimates cancer cell fractions in bulk RNA-seq data
by: Jiawei Huang, et al.
Published: (2024-05-01)

An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity
by: Xiaodan Yan, et al.
Published: (2024-12-01)

Microfluidics Facilitates the Development of Single-Cell RNA Sequencing
by: Yating Pan, et al.
Published: (2022-06-01)

Single-cell RNA sequencing for the study of kidney disease
by: Jiayi Zhu, et al.
Published: (2023-07-01)