Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception
Background: Little is known about the cumulative effect of HIV antiretroviral therapy (ART) and hormonal contraception (HC) on metabolism and inflammation in HIV-positive women. Methods: We conducted a cross-sectional assessment of markers for carbohydrate, lipid, bone metabolism, inflammation and c...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Journal of Virus Eradication |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020302971 |
| _version_ | 1819093570622062592 |
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| author | Nadia Kancheva Landolt Torsak Bunupuradah Jullapong Achalapong Pope Kosalaraksa Witaya Petdachai Chaiwat Ngampiyaskul Sasiwimol Ubolyam Narukjaporn Thammajaruk Stephen Kerr Jintanat Ananworanich |
| author_facet | Nadia Kancheva Landolt Torsak Bunupuradah Jullapong Achalapong Pope Kosalaraksa Witaya Petdachai Chaiwat Ngampiyaskul Sasiwimol Ubolyam Narukjaporn Thammajaruk Stephen Kerr Jintanat Ananworanich |
| author_sort | Nadia Kancheva Landolt |
| collection | DOAJ |
| description | Background: Little is known about the cumulative effect of HIV antiretroviral therapy (ART) and hormonal contraception (HC) on metabolism and inflammation in HIV-positive women. Methods: We conducted a cross-sectional assessment of markers for carbohydrate, lipid, bone metabolism, inflammation and coagulation in HIV-positive adolescents on ART and HC (n=37) versus on ART only (n=51) in Thailand. The Wilcoxon rank-sum test was used to assess differences between groups. Results: The median age was 19.5 years. Most adolescents (95%) were perinatally infected. All were on ART for a median of 9 years. HC used was progestin only (n=21); combined oral contraceptive (COC) tablets (n=6) for the whole study period or alternating between progestin only and COC (n=10). Prevalence of any metabolic abnormalities was 99%. Four biomarkers were significantly higher with HC vs no HC: insulin (10.3 vs 6.2μU/mL, P=0.002), insulin resistance (1.89 vs 1.19 mass units, P=0.005), 25-OH vitamin D (33.2 vs 20.2ng/mL, P<0.0001) and C-terminal telopeptide (690 vs 530ng/L, P=0.011). Triglycerides and D-dimer were significantly lower with HC (103 vs 139mg/dL, P=0.014 and 140 vs 155ng/mL, P=0.003, respectively). There was no relationship between the type of HC or ART and the above differences. Conclusion: Perinatally infected HIV-positive adolescents on ART in this pilot study had a high prevalence of metabolic abnormalities. Bone turnover markers and insulin resistance were significantly higher with HC. Research on the cumulative effect of HIV, ART and HC on metabolism and inflammation in adolescents with HIV is important in order to devise strategies for preventing and mitigating long-term comorbidities. |
| first_indexed | 2024-12-21T23:13:37Z |
| format | Article |
| id | doaj.art-03805cd0088b450b97eed4be72065eb5 |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-12-21T23:13:37Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-03805cd0088b450b97eed4be72065eb52022-12-21T18:46:58ZengElsevierJournal of Virus Eradication2055-66402017-01-01315660Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraceptionNadia Kancheva Landolt0Torsak Bunupuradah1Jullapong Achalapong2Pope Kosalaraksa3Witaya Petdachai4Chaiwat Ngampiyaskul5Sasiwimol Ubolyam6Narukjaporn Thammajaruk7Stephen Kerr8Jintanat Ananworanich9HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Corresponding author: Nadia Kancheva Landolt, HIV-NAT, Thai Red Cross AIDS Research Centre, 104 Rajdumri Road, Pathumwan, Bangkok, 10330, ThailandHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, ThailandChiang Rai Prachanukroh Hospital, Chiang Rai, ThailandFaculty of Medicine, Khon Kaen University, Khon Kaen, ThailandPhra Chomklao Hospital Hospital, Phetchaburi, ThailandPhrapokklao Hospital, Chanthaburi, ThailandHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, ThailandHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, ThailandHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Department of Global Health, University of Amsterdam, Amsterdam Institute for Global Health and Development, the NetherlandsHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USABackground: Little is known about the cumulative effect of HIV antiretroviral therapy (ART) and hormonal contraception (HC) on metabolism and inflammation in HIV-positive women. Methods: We conducted a cross-sectional assessment of markers for carbohydrate, lipid, bone metabolism, inflammation and coagulation in HIV-positive adolescents on ART and HC (n=37) versus on ART only (n=51) in Thailand. The Wilcoxon rank-sum test was used to assess differences between groups. Results: The median age was 19.5 years. Most adolescents (95%) were perinatally infected. All were on ART for a median of 9 years. HC used was progestin only (n=21); combined oral contraceptive (COC) tablets (n=6) for the whole study period or alternating between progestin only and COC (n=10). Prevalence of any metabolic abnormalities was 99%. Four biomarkers were significantly higher with HC vs no HC: insulin (10.3 vs 6.2μU/mL, P=0.002), insulin resistance (1.89 vs 1.19 mass units, P=0.005), 25-OH vitamin D (33.2 vs 20.2ng/mL, P<0.0001) and C-terminal telopeptide (690 vs 530ng/L, P=0.011). Triglycerides and D-dimer were significantly lower with HC (103 vs 139mg/dL, P=0.014 and 140 vs 155ng/mL, P=0.003, respectively). There was no relationship between the type of HC or ART and the above differences. Conclusion: Perinatally infected HIV-positive adolescents on ART in this pilot study had a high prevalence of metabolic abnormalities. Bone turnover markers and insulin resistance were significantly higher with HC. Research on the cumulative effect of HIV, ART and HC on metabolism and inflammation in adolescents with HIV is important in order to devise strategies for preventing and mitigating long-term comorbidities.http://www.sciencedirect.com/science/article/pii/S2055664020302971 |
| spellingShingle | Nadia Kancheva Landolt Torsak Bunupuradah Jullapong Achalapong Pope Kosalaraksa Witaya Petdachai Chaiwat Ngampiyaskul Sasiwimol Ubolyam Narukjaporn Thammajaruk Stephen Kerr Jintanat Ananworanich Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception Journal of Virus Eradication |
| title | Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception |
| title_full | Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception |
| title_fullStr | Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception |
| title_full_unstemmed | Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception |
| title_short | Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception |
| title_sort | carbohydrate lipid bone and inflammatory markers in hiv positive adolescents on antiretroviral therapy and hormonal contraception |
| url | http://www.sciencedirect.com/science/article/pii/S2055664020302971 |
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