Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-syn...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/5/2/282 |
| _version_ | 1819261226831577088 |
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| author | Hazel L. Roberts David R. Brown |
| author_facet | Hazel L. Roberts David R. Brown |
| author_sort | Hazel L. Roberts |
| collection | DOAJ |
| description | In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of “toxic oligomers”: a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described. |
| first_indexed | 2024-12-23T19:38:26Z |
| format | Article |
| id | doaj.art-0380f55dbfce48a88c2d81ca0c381903 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-23T19:38:26Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0380f55dbfce48a88c2d81ca0c3819032022-12-21T17:33:43ZengMDPI AGBiomolecules2218-273X2015-03-015228230510.3390/biom5020282biom5020282Seeking a Mechanism for the Toxicity of Oligomeric α-SynucleinHazel L. Roberts0David R. Brown1Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UKDepartment of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UKIn a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of “toxic oligomers”: a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described.http://www.mdpi.com/2218-273X/5/2/282α-synucleinneurodegenerationParkinson’s diseaseaggregationtoxic oligomersamyloid fibrils |
| spellingShingle | Hazel L. Roberts David R. Brown Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein Biomolecules α-synuclein neurodegeneration Parkinson’s disease aggregation toxic oligomers amyloid fibrils |
| title | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
| title_full | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
| title_fullStr | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
| title_full_unstemmed | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
| title_short | Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein |
| title_sort | seeking a mechanism for the toxicity of oligomeric α synuclein |
| topic | α-synuclein neurodegeneration Parkinson’s disease aggregation toxic oligomers amyloid fibrils |
| url | http://www.mdpi.com/2218-273X/5/2/282 |
| work_keys_str_mv | AT hazellroberts seekingamechanismforthetoxicityofoligomericasynuclein AT davidrbrown seekingamechanismforthetoxicityofoligomericasynuclein |