Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta
The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1–2 were prepared by semi-synthesis thorough acetylation of...
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| Format: | Article |
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MDPI AG
2014-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/4/3898 |
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| author | Jorge Bórquez Alejandro Ardiles Luis Alberto Loyola Luis Manuel Peña-Rodriguez Gloria María Molina-Salinas Javier Vallejos Isidro G. Collado Mario J. Simirgiotis |
| author_facet | Jorge Bórquez Alejandro Ardiles Luis Alberto Loyola Luis Manuel Peña-Rodriguez Gloria María Molina-Salinas Javier Vallejos Isidro G. Collado Mario J. Simirgiotis |
| author_sort | Jorge Bórquez |
| collection | DOAJ |
| description | The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1–2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods. |
| first_indexed | 2024-12-11T22:32:36Z |
| format | Article |
| id | doaj.art-03817baeb5134e02938f675873d1d80a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T22:32:36Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-03817baeb5134e02938f675873d1d80a2022-12-22T00:48:04ZengMDPI AGMolecules1420-30492014-03-011943898390810.3390/molecules19043898molecules19043898Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compactaJorge Bórquez0Alejandro Ardiles1Luis Alberto Loyola2Luis Manuel Peña-Rodriguez3Gloria María Molina-Salinas4Javier Vallejos5Isidro G. Collado6Mario J. Simirgiotis7Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, ChileLaboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, ChileLaboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, ChileGrupo de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No 130, Colonia Chuburná, Mérida, Yucatán 97200, MexicoDivisión de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, San Luis Potosí y Dos de Abril, Colonia Independencia, Monterrey, Nuevo León 64720, MexicoDepartamento de Química, Universidad Católica del Norte, Av. Angamos 610, Antofagasta 1240000, ChileDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apartado Postal 40, Puerto Real 11510, SpainLaboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, ChileThe new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1–2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.http://www.mdpi.com/1420-3049/19/4/3898mulinanesazorellanesnew diterpenoidsChilean native plantssemisynthesis |
| spellingShingle | Jorge Bórquez Alejandro Ardiles Luis Alberto Loyola Luis Manuel Peña-Rodriguez Gloria María Molina-Salinas Javier Vallejos Isidro G. Collado Mario J. Simirgiotis Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta Molecules mulinanes azorellanes new diterpenoids Chilean native plants semisynthesis |
| title | Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta |
| title_full | Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta |
| title_fullStr | Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta |
| title_full_unstemmed | Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta |
| title_short | Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta |
| title_sort | further mulinane and azorellane diterpenoids isolated from mulinum crassifolium and azorella compacta |
| topic | mulinanes azorellanes new diterpenoids Chilean native plants semisynthesis |
| url | http://www.mdpi.com/1420-3049/19/4/3898 |
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