Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
AbstractDNA methylation in bacteria frequently serves as a simple immune system, allowing recognition of DNA from foreign sources, such as phages or selfish genetic elements. However, DNA methylation also affects other cell phenotypes in a heritable manner (i.e. epigenetically). Whil...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2022-12-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac310 |
| _version_ | 1797785696545538048 |
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| author | Georgia L Breckell Olin K Silander |
| author_facet | Georgia L Breckell Olin K Silander |
| author_sort | Georgia L Breckell |
| collection | DOAJ |
| description |
AbstractDNA methylation in bacteria frequently serves as a simple immune system, allowing recognition of DNA from foreign sources, such as phages or selfish genetic elements. However, DNA methylation also affects other cell phenotypes in a heritable manner (i.e. epigenetically). While there are several examples of methylation affecting transcription in an epigenetic manner in highly localized contexts, it is not well-established how frequently methylation serves a more general epigenetic function over larger genomic scales. To address this question, here we use Oxford Nanopore sequencing to profile DNA modification marks in three natural isolates of Escherichia coliE. coli |
| first_indexed | 2024-03-13T00:57:41Z |
| format | Article |
| id | doaj.art-0381f6adfe894369b54c95710487628a |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-03-13T00:57:41Z |
| publishDate | 2022-12-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-0381f6adfe894369b54c95710487628a2023-07-06T14:25:44ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362022-12-0113210.1093/g3journal/jkac310Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i> Georgia L Breckell0Olin K Silander1https://orcid.org/0000-0003-4105-8316School of Natural and Sciences, Massey University, Auckland 0745, New ZealandSchool of Natural and Sciences, Massey University, Auckland 0745, New Zealand AbstractDNA methylation in bacteria frequently serves as a simple immune system, allowing recognition of DNA from foreign sources, such as phages or selfish genetic elements. However, DNA methylation also affects other cell phenotypes in a heritable manner (i.e. epigenetically). While there are several examples of methylation affecting transcription in an epigenetic manner in highly localized contexts, it is not well-established how frequently methylation serves a more general epigenetic function over larger genomic scales. To address this question, here we use Oxford Nanopore sequencing to profile DNA modification marks in three natural isolates of Escherichia coliE. colihttps://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac310 |
| spellingShingle | Georgia L Breckell Olin K Silander Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i> G3: Genes, Genomes, Genetics |
| title | Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
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| title_full | Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
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| title_fullStr | Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
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| title_full_unstemmed | Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
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| title_short | Growth condition-dependent differences in methylation imply transiently differentiated DNA methylation states in <i>Escherichia coli</i>
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| title_sort | growth condition dependent differences in methylation imply transiently differentiated dna methylation states in i escherichia coli i |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac310 |
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