Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence
Background: Cognitive impairment is a major challenge for elderlies, as it can progress in a rapid manner and effective treatments are limited. Sarcopenic elderlies have a higher risk of dementia. This scoping review aims to reveal whether muscle is a mediator of cognitive function from pre-clinical...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X22001012 |
| _version_ | 1797904329616654336 |
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| author | Chaoran Liu Pui Yan Wong Simon Kwoon Ho Chow Wing Hoi Cheung Ronald Man Yeung Wong |
| author_facet | Chaoran Liu Pui Yan Wong Simon Kwoon Ho Chow Wing Hoi Cheung Ronald Man Yeung Wong |
| author_sort | Chaoran Liu |
| collection | DOAJ |
| description | Background: Cognitive impairment is a major challenge for elderlies, as it can progress in a rapid manner and effective treatments are limited. Sarcopenic elderlies have a higher risk of dementia. This scoping review aims to reveal whether muscle is a mediator of cognitive function from pre-clinical evidence. Methods: PubMed, Embase, and Web of Science were searched to Feb 2nd, 2022, using the keywords (muscle) AND (cognition OR dementia OR Alzheimer) AND (mouse OR rat OR animal). The PRISMA guideline was used in this study. Results: A total of 17 pre-clinical studies were selected from 7638 studies. 4 studies reported that muscle atrophy and injury harmed memory, functional factors, and neurons in the brain for rodents with or without Alzheimer's disease (AD). 3 studies observed exercise induced muscle to secrete factors, including lactate, fibronectin type III domain-containing protein 5 (FNDC5), and cathepsin B, which plays essential roles in the elevation of cognitive functions and brain-derived neurotrophic factor (BDNF) levels. Muscle-targeted treatments including electrical stimulation and intramuscular injections had effective remote effects on the hippocampus. 6 studies showed that muscle-specific overexpression of scFv59 and Neprilysin, or myostatin knockdown alleviated AD symptoms. 1 study showed that muscle insulin resistance also led to deficient hippocampal neurogenesis in MKR mice. Conclusions: The skeletal muscle is involved in the mediation of cognitive function. The evidence was established by the response in the brain (altered number of neurons, functional factors, and other AD pathological characteristics) with muscle atrophy or injury, muscle secretory factors, and muscle-targeted treatments. The translational potential of this paper: This study summarizes the current evidence in how muscle affects cognition in molecular levels, which supports muscle-specific treatments as potential clinical strategies to prevent cognitive dysfunction. |
| first_indexed | 2024-04-10T09:47:12Z |
| format | Article |
| id | doaj.art-0386b4df9a7e461a8973585b5cfbe0e5 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-10T09:47:12Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-0386b4df9a7e461a8973585b5cfbe0e52023-02-17T04:54:24ZengElsevierJournal of Orthopaedic Translation2214-031X2023-01-01387683Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidenceChaoran Liu0Pui Yan Wong1Simon Kwoon Ho Chow2Wing Hoi Cheung3Ronald Man Yeung Wong4Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, ChinaCorresponding author. Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, 5/F, Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Hong Kong SAR, China.; Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, ChinaBackground: Cognitive impairment is a major challenge for elderlies, as it can progress in a rapid manner and effective treatments are limited. Sarcopenic elderlies have a higher risk of dementia. This scoping review aims to reveal whether muscle is a mediator of cognitive function from pre-clinical evidence. Methods: PubMed, Embase, and Web of Science were searched to Feb 2nd, 2022, using the keywords (muscle) AND (cognition OR dementia OR Alzheimer) AND (mouse OR rat OR animal). The PRISMA guideline was used in this study. Results: A total of 17 pre-clinical studies were selected from 7638 studies. 4 studies reported that muscle atrophy and injury harmed memory, functional factors, and neurons in the brain for rodents with or without Alzheimer's disease (AD). 3 studies observed exercise induced muscle to secrete factors, including lactate, fibronectin type III domain-containing protein 5 (FNDC5), and cathepsin B, which plays essential roles in the elevation of cognitive functions and brain-derived neurotrophic factor (BDNF) levels. Muscle-targeted treatments including electrical stimulation and intramuscular injections had effective remote effects on the hippocampus. 6 studies showed that muscle-specific overexpression of scFv59 and Neprilysin, or myostatin knockdown alleviated AD symptoms. 1 study showed that muscle insulin resistance also led to deficient hippocampal neurogenesis in MKR mice. Conclusions: The skeletal muscle is involved in the mediation of cognitive function. The evidence was established by the response in the brain (altered number of neurons, functional factors, and other AD pathological characteristics) with muscle atrophy or injury, muscle secretory factors, and muscle-targeted treatments. The translational potential of this paper: This study summarizes the current evidence in how muscle affects cognition in molecular levels, which supports muscle-specific treatments as potential clinical strategies to prevent cognitive dysfunction.http://www.sciencedirect.com/science/article/pii/S2214031X22001012MuscleCognitive functionBrainAnimal modelReview |
| spellingShingle | Chaoran Liu Pui Yan Wong Simon Kwoon Ho Chow Wing Hoi Cheung Ronald Man Yeung Wong Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence Journal of Orthopaedic Translation Muscle Cognitive function Brain Animal model Review |
| title | Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence |
| title_full | Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence |
| title_fullStr | Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence |
| title_full_unstemmed | Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence |
| title_short | Does the regulation of skeletal muscle influence cognitive function? A scoping review of pre-clinical evidence |
| title_sort | does the regulation of skeletal muscle influence cognitive function a scoping review of pre clinical evidence |
| topic | Muscle Cognitive function Brain Animal model Review |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X22001012 |
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