Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid

Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid

The ventral tegmental area (VTA) is a midbrain region highly involved in motivation and reward. A large body of work has investigated synaptic plasticity and ion channel excitability in this area, which has strong implication in drug abuse. We recently provided electrophysiological and pharmacologic...

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Bibliographic Details
Main Authors: Taylor Joel Woodward, Vesna Tesic, Tamara Timic Stamenic, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
ventral tegmental area
gamma-amino-butyric acid
T-type calcium channel
lipoic acid
rebound spiking
burst firing
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01402/full

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