SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study
Our previous study suggested that the synapse-associated protein 97 (SAP97) gene rs3915512 polymorphism may influence neurocognition in schizophrenia patients. Neuroimaging studies have shown a possible association between cognitive function and brain activity/connectivity. Considering the poor unde...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-10-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2020.572414/full |
_version_ | 1818333318062538752 |
---|---|
author | Xusan Xu Xusan Xu Bin He Zhixiong Lin Xiaoxia Wang Jingwen Yin Xudong Luo Shucun Luo Chunmei Liang Xia Wen Susu Xiong Dongjian Zhu Jiawu Fu Dong Lv Zhun Dai Juda Lin You Li Wubiao Chen Zebin Luo Yajun Wang Guoda Ma Guoda Ma |
author_facet | Xusan Xu Xusan Xu Bin He Zhixiong Lin Xiaoxia Wang Jingwen Yin Xudong Luo Shucun Luo Chunmei Liang Xia Wen Susu Xiong Dongjian Zhu Jiawu Fu Dong Lv Zhun Dai Juda Lin You Li Wubiao Chen Zebin Luo Yajun Wang Guoda Ma Guoda Ma |
author_sort | Xusan Xu |
collection | DOAJ |
description | Our previous study suggested that the synapse-associated protein 97 (SAP97) gene rs3915512 polymorphism may influence neurocognition in schizophrenia patients. Neuroimaging studies have shown a possible association between cognitive function and brain activity/connectivity. Considering the poor understanding of whether the disease state and SAP97 rs3915512 polymorphism have interactive effects on brain activity/connectivity, 52 first-episode schizophrenia (FES) patients and 52 healthy controls were genotyped using blood DNA samples and underwent magnetic resonance imaging scanning. A two-way ANCOVA model was performed with rs3915512 genotypes and disease state as the between-subject factors. A significant disease × SAP97 interactive effect was found for the amplitude of low-frequency fluctuation (ALFF) in the right supplementary motor area, left rolandic opercularis area (ROC-L), and bilateral middle occipital gyrus (MOG). In addition, among auditory/visual-related brain areas, a significant interactive effect was found for resting-state functional connectivity (RSFC) between the MOG-L and bilateral superior temporal gyrus (STG) in the STG-L with ROC-R, right cuneus (Cu-R), left fusiform (Fu-L), and left lingual gyrus (LG-L). Positive correlations were found between ALFF in the ROC-L and motor speed scores, between RSFC in the STG-L and LG-L and between Brief Assessment of Cognition in Schizophrenia verbal memory scores in FES. The SAP97 rs3915512 polymorphism may affect neurocognitive function in patients with schizophrenia by changing the brain activity and connectivity of auditory/visual-related brain areas. |
first_indexed | 2024-12-13T13:49:44Z |
format | Article |
id | doaj.art-0387c4e56c8d4f29b192ef2f06fc1f01 |
institution | Directory Open Access Journal |
issn | 1664-8021 |
language | English |
last_indexed | 2024-12-13T13:49:44Z |
publishDate | 2020-10-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Genetics |
spelling | doaj.art-0387c4e56c8d4f29b192ef2f06fc1f012022-12-21T23:43:16ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-10-011110.3389/fgene.2020.572414572414SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging StudyXusan Xu0Xusan Xu1Bin He2Zhixiong Lin3Xiaoxia Wang4Jingwen Yin5Xudong Luo6Shucun Luo7Chunmei Liang8Xia Wen9Susu Xiong10Dongjian Zhu11Jiawu Fu12Dong Lv13Zhun Dai14Juda Lin15You Li16Wubiao Chen17Zebin Luo18Yajun Wang19Guoda Ma20Guoda Ma21Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaMaternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaClinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaInstitute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaMaternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan, ChinaOur previous study suggested that the synapse-associated protein 97 (SAP97) gene rs3915512 polymorphism may influence neurocognition in schizophrenia patients. Neuroimaging studies have shown a possible association between cognitive function and brain activity/connectivity. Considering the poor understanding of whether the disease state and SAP97 rs3915512 polymorphism have interactive effects on brain activity/connectivity, 52 first-episode schizophrenia (FES) patients and 52 healthy controls were genotyped using blood DNA samples and underwent magnetic resonance imaging scanning. A two-way ANCOVA model was performed with rs3915512 genotypes and disease state as the between-subject factors. A significant disease × SAP97 interactive effect was found for the amplitude of low-frequency fluctuation (ALFF) in the right supplementary motor area, left rolandic opercularis area (ROC-L), and bilateral middle occipital gyrus (MOG). In addition, among auditory/visual-related brain areas, a significant interactive effect was found for resting-state functional connectivity (RSFC) between the MOG-L and bilateral superior temporal gyrus (STG) in the STG-L with ROC-R, right cuneus (Cu-R), left fusiform (Fu-L), and left lingual gyrus (LG-L). Positive correlations were found between ALFF in the ROC-L and motor speed scores, between RSFC in the STG-L and LG-L and between Brief Assessment of Cognition in Schizophrenia verbal memory scores in FES. The SAP97 rs3915512 polymorphism may affect neurocognitive function in patients with schizophrenia by changing the brain activity and connectivity of auditory/visual-related brain areas.https://www.frontiersin.org/article/10.3389/fgene.2020.572414/fullschizophreniaSAP97rs3915512cognitive functionsALFFRSFC |
spellingShingle | Xusan Xu Xusan Xu Bin He Zhixiong Lin Xiaoxia Wang Jingwen Yin Xudong Luo Shucun Luo Chunmei Liang Xia Wen Susu Xiong Dongjian Zhu Jiawu Fu Dong Lv Zhun Dai Juda Lin You Li Wubiao Chen Zebin Luo Yajun Wang Guoda Ma Guoda Ma SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study Frontiers in Genetics schizophrenia SAP97 rs3915512 cognitive functions ALFF RSFC |
title | SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study |
title_full | SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study |
title_fullStr | SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study |
title_full_unstemmed | SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study |
title_short | SAP97 rs3915512 Polymorphism Affects the Neurocognition of Schizophrenic Patients: A Genetic Neuroimaging Study |
title_sort | sap97 rs3915512 polymorphism affects the neurocognition of schizophrenic patients a genetic neuroimaging study |
topic | schizophrenia SAP97 rs3915512 cognitive functions ALFF RSFC |
url | https://www.frontiersin.org/article/10.3389/fgene.2020.572414/full |
work_keys_str_mv | AT xusanxu sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT xusanxu sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT binhe sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT zhixionglin sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT xiaoxiawang sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT jingwenyin sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT xudongluo sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT shucunluo sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT chunmeiliang sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT xiawen sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT susuxiong sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT dongjianzhu sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT jiawufu sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT donglv sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT zhundai sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT judalin sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT youli sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT wubiaochen sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT zebinluo sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT yajunwang sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT guodama sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy AT guodama sap97rs3915512polymorphismaffectstheneurocognitionofschizophrenicpatientsageneticneuroimagingstudy |