Multiplexed coding by cerebellar Purkinje neurons
Purkinje cells (PC), the sole output neurons of the cerebellar cortex, encode sensorimotor information, but how they do it remains a matter of debate. Here we show that PCs use a multiplexed spike code. Synchrony/spike time and firing rate encode different information in behaving monkeys during sacc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/13810 |
| _version_ | 1811200409457393664 |
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| author | Sungho Hong Mario Negrello Marc Junker Aleksandra Smilgin Peter Thier Erik De Schutter |
| author_facet | Sungho Hong Mario Negrello Marc Junker Aleksandra Smilgin Peter Thier Erik De Schutter |
| author_sort | Sungho Hong |
| collection | DOAJ |
| description | Purkinje cells (PC), the sole output neurons of the cerebellar cortex, encode sensorimotor information, but how they do it remains a matter of debate. Here we show that PCs use a multiplexed spike code. Synchrony/spike time and firing rate encode different information in behaving monkeys during saccadic eye motion tasks. Using the local field potential (LFP) as a probe of local network activity, we found that infrequent pause spikes, which initiated or terminated intermittent pauses in simple spike trains, provide a temporally reliable signal for eye motion onset, with strong phase-coupling to the β/γ band LFP. Concurrently, regularly firing, non-pause spikes were weakly correlated with the LFP, but were crucial to linear encoding of eye movement kinematics by firing rate. Therefore, PC spike trains can simultaneously convey information necessary to achieve precision in both timing and continuous control of motion. |
| first_indexed | 2024-04-12T02:04:10Z |
| format | Article |
| id | doaj.art-038993b8be2d4044988a6f8091b3d123 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:04:10Z |
| publishDate | 2016-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-038993b8be2d4044988a6f8091b3d1232022-12-22T03:52:35ZengeLife Sciences Publications LtdeLife2050-084X2016-07-01510.7554/eLife.13810Multiplexed coding by cerebellar Purkinje neuronsSungho Hong0https://orcid.org/0000-0002-6905-7932Mario Negrello1Marc Junker2Aleksandra Smilgin3Peter Thier4Erik De Schutter5Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, JapanComputational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan; Department of Neuroscience, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanyDepartment of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanyDepartment of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanyComputational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, JapanPurkinje cells (PC), the sole output neurons of the cerebellar cortex, encode sensorimotor information, but how they do it remains a matter of debate. Here we show that PCs use a multiplexed spike code. Synchrony/spike time and firing rate encode different information in behaving monkeys during saccadic eye motion tasks. Using the local field potential (LFP) as a probe of local network activity, we found that infrequent pause spikes, which initiated or terminated intermittent pauses in simple spike trains, provide a temporally reliable signal for eye motion onset, with strong phase-coupling to the β/γ band LFP. Concurrently, regularly firing, non-pause spikes were weakly correlated with the LFP, but were crucial to linear encoding of eye movement kinematics by firing rate. Therefore, PC spike trains can simultaneously convey information necessary to achieve precision in both timing and continuous control of motion.https://elifesciences.org/articles/13810neural codingcerebellumPurkinje cellsensorimotor system |
| spellingShingle | Sungho Hong Mario Negrello Marc Junker Aleksandra Smilgin Peter Thier Erik De Schutter Multiplexed coding by cerebellar Purkinje neurons eLife neural coding cerebellum Purkinje cell sensorimotor system |
| title | Multiplexed coding by cerebellar Purkinje neurons |
| title_full | Multiplexed coding by cerebellar Purkinje neurons |
| title_fullStr | Multiplexed coding by cerebellar Purkinje neurons |
| title_full_unstemmed | Multiplexed coding by cerebellar Purkinje neurons |
| title_short | Multiplexed coding by cerebellar Purkinje neurons |
| title_sort | multiplexed coding by cerebellar purkinje neurons |
| topic | neural coding cerebellum Purkinje cell sensorimotor system |
| url | https://elifesciences.org/articles/13810 |
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