Is creatine a CNS neurotransmitter?

A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.

Bibliographic Details
Main Authors: Bhagaban Mallik, C Andrew Frank
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/91824
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author Bhagaban Mallik
C Andrew Frank
author_facet Bhagaban Mallik
C Andrew Frank
author_sort Bhagaban Mallik
collection DOAJ
description A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.
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spelling doaj.art-038bf1304d964c9f8664989fe023b9c52023-10-16T15:08:10ZengeLife Sciences Publications LtdeLife2050-084X2023-10-011210.7554/eLife.91824Is creatine a CNS neurotransmitter?Bhagaban Mallik0https://orcid.org/0000-0001-7637-3338C Andrew Frank1https://orcid.org/0000-0001-9599-421XDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, United StatesDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, United StatesA range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.https://elifesciences.org/articles/91824creatineinhibitory neurotransmissionsynaptic vesiclesastrocytesSLC6A8AGAT
spellingShingle Bhagaban Mallik
C Andrew Frank
Is creatine a CNS neurotransmitter?
eLife
creatine
inhibitory neurotransmission
synaptic vesicles
astrocytes
SLC6A8
AGAT
title Is creatine a CNS neurotransmitter?
title_full Is creatine a CNS neurotransmitter?
title_fullStr Is creatine a CNS neurotransmitter?
title_full_unstemmed Is creatine a CNS neurotransmitter?
title_short Is creatine a CNS neurotransmitter?
title_sort is creatine a cns neurotransmitter
topic creatine
inhibitory neurotransmission
synaptic vesicles
astrocytes
SLC6A8
AGAT
url https://elifesciences.org/articles/91824
work_keys_str_mv AT bhagabanmallik iscreatineacnsneurotransmitter
AT candrewfrank iscreatineacnsneurotransmitter