The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression

The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression

Abstract Background Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many cancers. It is known to epigenetically stimulate the expression of genes...

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Bibliographic Details
Main Authors: Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou, Erhao Zhang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
KMT2D
Low-complexity domain
Liquid–liquid phase separation
H3K4 monomethylation
Epigenetic therapy
Online Access:https://doi.org/10.1186/s11658-021-00292-7

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