Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men
Abstract There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23225-6 |
| _version_ | 1828156094678040576 |
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| author | Stanley Teleka Marju Orho-Melander Fredrik Liedberg Olle Melander Karin Jirström Tanja Stocks |
| author_facet | Stanley Teleka Marju Orho-Melander Fredrik Liedberg Olle Melander Karin Jirström Tanja Stocks |
| author_sort | Stanley Teleka |
| collection | DOAJ |
| description | Abstract There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic variants, BP, and their interaction, in relation to incident urothelial cancer (UC, n = 385) risk in 10,576 men. We used Cox regression, the likelihood ratio test, and the relative excess risk for interaction to calculate hazard ratios (HR) of UC, multiplicative interaction and additive interaction respectively. There was evidence of a positive additive interaction between SBP and the wGRS in relation to aggressive (P = 0.02) but not non-aggressive (P = 0.60) UC. The HR of aggressive UC was for SBP ≥ 140 mmHg and the upper 50% of the wGRS combined 1.72 (95% CI 1.03–2.87) compared to the counterpart group. Additionally, the 20-year risk of aggressive UC in 60 year-old men was 0.78% in the low SBP/low wGRS group and 1.33% in the high SBP/high wGRS group. Our findings support a potential additive interaction between the wGRS and SBP on aggressive UC among men. If replicated, the findings on interaction may provide biological and public health insight to prevent aggressive UC. |
| first_indexed | 2024-04-11T23:04:32Z |
| format | Article |
| id | doaj.art-038fb0fc799a4b38a012f39a296985ca |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T23:04:32Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-038fb0fc799a4b38a012f39a296985ca2022-12-22T03:58:02ZengNature PortfolioScientific Reports2045-23222022-10-0112111010.1038/s41598-022-23225-6Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in menStanley Teleka0Marju Orho-Melander1Fredrik Liedberg2Olle Melander3Karin Jirström4Tanja Stocks5Department of Surgical Sciences, Uppsala UniversityDepartment of Clinical Sciences in Malmö, Lund UniversityDepartment of Urology, Skåne University Hospital MalmöDepartment of Clinical Sciences in Malmö, Lund UniversityDepartment of Clinical Sciences in Lund, Lund UniversityDepartment of Clinical Sciences in Lund, Lund UniversityAbstract There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic variants, BP, and their interaction, in relation to incident urothelial cancer (UC, n = 385) risk in 10,576 men. We used Cox regression, the likelihood ratio test, and the relative excess risk for interaction to calculate hazard ratios (HR) of UC, multiplicative interaction and additive interaction respectively. There was evidence of a positive additive interaction between SBP and the wGRS in relation to aggressive (P = 0.02) but not non-aggressive (P = 0.60) UC. The HR of aggressive UC was for SBP ≥ 140 mmHg and the upper 50% of the wGRS combined 1.72 (95% CI 1.03–2.87) compared to the counterpart group. Additionally, the 20-year risk of aggressive UC in 60 year-old men was 0.78% in the low SBP/low wGRS group and 1.33% in the high SBP/high wGRS group. Our findings support a potential additive interaction between the wGRS and SBP on aggressive UC among men. If replicated, the findings on interaction may provide biological and public health insight to prevent aggressive UC.https://doi.org/10.1038/s41598-022-23225-6 |
| spellingShingle | Stanley Teleka Marju Orho-Melander Fredrik Liedberg Olle Melander Karin Jirström Tanja Stocks Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men Scientific Reports |
| title | Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men |
| title_full | Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men |
| title_fullStr | Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men |
| title_full_unstemmed | Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men |
| title_short | Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men |
| title_sort | interaction between blood pressure and genetic risk score for bladder cancer and risk of urothelial carcinoma in men |
| url | https://doi.org/10.1038/s41598-022-23225-6 |
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