Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis
Alzheimer’s disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. For current diagnostics capable of identifying AD, the development and validation of early stage biomarkers is a top research priority. Body-fluid biomarkers might closely r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/10/5/326 |
| _version_ | 1827716489689432064 |
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| author | Thuy Trang Nguyen Qui Thanh Hoai Ta Thi Kim Oanh Nguyen Thi Thuy Dung Nguyen Van Giau Vo |
| author_facet | Thuy Trang Nguyen Qui Thanh Hoai Ta Thi Kim Oanh Nguyen Thi Thuy Dung Nguyen Van Giau Vo |
| author_sort | Thuy Trang Nguyen |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. For current diagnostics capable of identifying AD, the development and validation of early stage biomarkers is a top research priority. Body-fluid biomarkers might closely reflect synaptic dysfunction in the brain and, thereby, could contribute to improving diagnostic accuracy and monitoring disease progression, and serve as markers for assessing the response to disease-modifying therapies at early onset. Here, we highlight current advances in the research on the capabilities of body-fluid biomarkers and their role in AD pathology. Then, we describe and discuss current applications of the potential biomarkers in clinical diagnostics in AD. |
| first_indexed | 2024-03-10T19:42:25Z |
| format | Article |
| id | doaj.art-038fdc4f77f34faf8584031efef2e1ad |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T19:42:25Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-038fdc4f77f34faf8584031efef2e1ad2023-11-20T01:07:35ZengMDPI AGDiagnostics2075-44182020-05-0110532610.3390/diagnostics10050326Role of Body-Fluid Biomarkers in Alzheimer’s Disease DiagnosisThuy Trang Nguyen0Qui Thanh Hoai Ta1Thi Kim Oanh Nguyen2Thi Thuy Dung Nguyen3Van Giau Vo4Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City 700000, VietnamInstitute of Research and Development, Duy Tan University, Danang 550000, VietnamFaculty of Food Science and Technology, Ho Chi Minh City University of Food Industry, Ho Chi Minh City 700000, VietnamFaculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City 70000, VietnamDepartment of Industrial and Environmental Engineering, Graduate School of Environment, Gachon University, 1342 Sungnam-daero, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, KoreaAlzheimer’s disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. For current diagnostics capable of identifying AD, the development and validation of early stage biomarkers is a top research priority. Body-fluid biomarkers might closely reflect synaptic dysfunction in the brain and, thereby, could contribute to improving diagnostic accuracy and monitoring disease progression, and serve as markers for assessing the response to disease-modifying therapies at early onset. Here, we highlight current advances in the research on the capabilities of body-fluid biomarkers and their role in AD pathology. Then, we describe and discuss current applications of the potential biomarkers in clinical diagnostics in AD.https://www.mdpi.com/2075-4418/10/5/326Alzheimer’s diseasebiomarkersdiagnosticsAβCSFtau |
| spellingShingle | Thuy Trang Nguyen Qui Thanh Hoai Ta Thi Kim Oanh Nguyen Thi Thuy Dung Nguyen Van Giau Vo Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis Diagnostics Alzheimer’s disease biomarkers diagnostics Aβ CSF tau |
| title | Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis |
| title_full | Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis |
| title_fullStr | Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis |
| title_full_unstemmed | Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis |
| title_short | Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis |
| title_sort | role of body fluid biomarkers in alzheimer s disease diagnosis |
| topic | Alzheimer’s disease biomarkers diagnostics Aβ CSF tau |
| url | https://www.mdpi.com/2075-4418/10/5/326 |
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