A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain, called VeDTR, in which T-bet/Foxp3 double-positi...

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Bibliographic Details
Main Authors: Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008240

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