Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?
Calorie restriction (CR) has been shown to extend lifespan and retard aging-related functional decline in animals. Previously, we found that the anti-neoplastic and lifespan-extending effects of CR in mice are regulated by forkhead box O transcription factors (FoxO1 and FoxO3), located downstream of...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/1959 |
| _version_ | 1797563691976097792 |
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| author | Sang-Eun Kim Ryoichi Mori Isao Shimokawa |
| author_facet | Sang-Eun Kim Ryoichi Mori Isao Shimokawa |
| author_sort | Sang-Eun Kim |
| collection | DOAJ |
| description | Calorie restriction (CR) has been shown to extend lifespan and retard aging-related functional decline in animals. Previously, we found that the anti-neoplastic and lifespan-extending effects of CR in mice are regulated by forkhead box O transcription factors (FoxO1 and FoxO3), located downstream of growth hormone (GH)–insulin-like growth factor (IGF)-1 signaling, in an isoform-specific manner. Inflammaging is a term coined to represent that persistent low-level of inflammation underlies the progression of aging and related diseases. Attenuation of inflammaging in the body may underlie the effects of CR. Recent studies have also identified cellular senescence and activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome as causative factors of inflammaging. In this paper, we reviewed the current knowledge of the molecular mechanisms linking the effects of CR with the formation of inflammasomes, particularly focusing on possible relations with FoxO3. Inflammation in the brain that affects adult neurogenesis and lifespan was also reviewed as evidence of inflammaging. A recent progress of microRNA research was described as regulatory circuits of initiation and propagation of inflammaging. Finally, we briefly introduced our preliminary results obtained from the mouse models, in which <i>Foxo1</i> and <i>Foxo3</i> genes were conditionally knocked out in the myeloid cell lineage. |
| first_indexed | 2024-03-10T18:46:05Z |
| format | Article |
| id | doaj.art-03918732be15477cbc86b77a1a3b1df5 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:46:05Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-03918732be15477cbc86b77a1a3b1df52023-11-20T05:27:24ZengMDPI AGNutrients2072-66432020-06-01127195910.3390/nu12071959Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?Sang-Eun Kim0Ryoichi Mori1Isao Shimokawa2Department of Pathology, School of Medicine and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanDepartment of Pathology, School of Medicine and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanDepartment of Pathology, School of Medicine and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanCalorie restriction (CR) has been shown to extend lifespan and retard aging-related functional decline in animals. Previously, we found that the anti-neoplastic and lifespan-extending effects of CR in mice are regulated by forkhead box O transcription factors (FoxO1 and FoxO3), located downstream of growth hormone (GH)–insulin-like growth factor (IGF)-1 signaling, in an isoform-specific manner. Inflammaging is a term coined to represent that persistent low-level of inflammation underlies the progression of aging and related diseases. Attenuation of inflammaging in the body may underlie the effects of CR. Recent studies have also identified cellular senescence and activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome as causative factors of inflammaging. In this paper, we reviewed the current knowledge of the molecular mechanisms linking the effects of CR with the formation of inflammasomes, particularly focusing on possible relations with FoxO3. Inflammation in the brain that affects adult neurogenesis and lifespan was also reviewed as evidence of inflammaging. A recent progress of microRNA research was described as regulatory circuits of initiation and propagation of inflammaging. Finally, we briefly introduced our preliminary results obtained from the mouse models, in which <i>Foxo1</i> and <i>Foxo3</i> genes were conditionally knocked out in the myeloid cell lineage.https://www.mdpi.com/2072-6643/12/7/1959calorie restrictionFoxOinflammagingNLRP3 inflammasomecellular senescence |
| spellingShingle | Sang-Eun Kim Ryoichi Mori Isao Shimokawa Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? Nutrients calorie restriction FoxO inflammaging NLRP3 inflammasome cellular senescence |
| title | Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? |
| title_full | Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? |
| title_fullStr | Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? |
| title_full_unstemmed | Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? |
| title_short | Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors? |
| title_sort | does calorie restriction modulate inflammaging via foxo transcription factors |
| topic | calorie restriction FoxO inflammaging NLRP3 inflammasome cellular senescence |
| url | https://www.mdpi.com/2072-6643/12/7/1959 |
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