Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

Small-molecule protein kinase inhibitors are used for the treatment of cancer, but off-target effects hinder their clinical use. Especially off-target activation of the pregnane X receptor (PXR) has to be considered, as it not only governs drug metabolism and elimination, but also can promote tumor...

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Bibliographic Details
Main Authors: Enni-Kaisa Mustonen, Tatu Pantsar, Azam Rashidian, Juliander Reiner, Matthias Schwab, Stefan Laufer, Oliver Burk
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
pregnane X receptor
protein kinase inhibitor
PXR antagonist
cancer therapy
Online Access:https://www.mdpi.com/2073-4409/11/8/1299

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