3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications
Magnetic nanoparticles based on iron oxide attract researchers’ attention due to a wide range of possible applications in biomedicine. As synthesized, most of the magnetic nanoparticles do not form the stable colloidal solutions that are required for the evaluation of their interactions with cells o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/9/461 |
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| author | Alevtina Semkina Aleksey Nikitin Anna Ivanova Nelly Chmelyuk Natalia Sviridenkova Polina Lazareva Maxim Abakumov |
| author_facet | Alevtina Semkina Aleksey Nikitin Anna Ivanova Nelly Chmelyuk Natalia Sviridenkova Polina Lazareva Maxim Abakumov |
| author_sort | Alevtina Semkina |
| collection | DOAJ |
| description | Magnetic nanoparticles based on iron oxide attract researchers’ attention due to a wide range of possible applications in biomedicine. As synthesized, most of the magnetic nanoparticles do not form the stable colloidal solutions that are required for the evaluation of their interactions with cells or their efficacy on animal models. For further application in biomedicine, magnetic nanoparticles must be further modified with biocompatible coating. Both the size and shape of magnetic nanoparticles and the chemical composition of the coating have an effect on magnetic nanoparticles’ interactions with living objects. Thus, a universal method for magnetic nanoparticles’ stabilization in water solutions is needed, regardless of how magnetic nanoparticles were initially synthesized. In this paper, we propose the versatile and highly reproducible ligand exchange technique of coating with 3,4-dihydroxiphenylacetic acid (DOPAC), based on the formation of Fe-O bonds with hydroxyl groups of DOPAC leading to the hydrophilization of the magnetic nanoparticles’ surfaces following phase transfer from organic solutions to water. The proposed technique allows for obtaining stable water–colloidal solutions of magnetic nanoparticles with sizes from 21 to 307 nm synthesized by thermal decomposition or coprecipitation techniques. Those stabilized by DOPAC nanoparticles were shown to be efficient in the magnetomechanical actuation of DNA duplexes, drug delivery of doxorubicin to cancer cells, and targeted delivery by conjugation with antibodies. Moreover, the diversity of possible biomedical applications of the resulting nanoparticles was presented. This finding is important in terms of nanoparticle design for various biomedical applications and will reduce nanomedicines manufacturing time, along with difficulties related to comparative studies of magnetic nanoparticles with different magnetic core characteristics. |
| first_indexed | 2024-03-10T22:35:45Z |
| format | Article |
| id | doaj.art-03925d7a68d240bb9a9f44fb57e4ae7a |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T22:35:45Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-03925d7a68d240bb9a9f44fb57e4ae7a2023-11-19T11:23:25ZengMDPI AGJournal of Functional Biomaterials2079-49832023-09-0114946110.3390/jfb140904613,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical ApplicationsAlevtina Semkina0Aleksey Nikitin1Anna Ivanova2Nelly Chmelyuk3Natalia Sviridenkova4Polina Lazareva5Maxim Abakumov6Department of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of General and Inorganic Chemistry, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, RussiaDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, RussiaMagnetic nanoparticles based on iron oxide attract researchers’ attention due to a wide range of possible applications in biomedicine. As synthesized, most of the magnetic nanoparticles do not form the stable colloidal solutions that are required for the evaluation of their interactions with cells or their efficacy on animal models. For further application in biomedicine, magnetic nanoparticles must be further modified with biocompatible coating. Both the size and shape of magnetic nanoparticles and the chemical composition of the coating have an effect on magnetic nanoparticles’ interactions with living objects. Thus, a universal method for magnetic nanoparticles’ stabilization in water solutions is needed, regardless of how magnetic nanoparticles were initially synthesized. In this paper, we propose the versatile and highly reproducible ligand exchange technique of coating with 3,4-dihydroxiphenylacetic acid (DOPAC), based on the formation of Fe-O bonds with hydroxyl groups of DOPAC leading to the hydrophilization of the magnetic nanoparticles’ surfaces following phase transfer from organic solutions to water. The proposed technique allows for obtaining stable water–colloidal solutions of magnetic nanoparticles with sizes from 21 to 307 nm synthesized by thermal decomposition or coprecipitation techniques. Those stabilized by DOPAC nanoparticles were shown to be efficient in the magnetomechanical actuation of DNA duplexes, drug delivery of doxorubicin to cancer cells, and targeted delivery by conjugation with antibodies. Moreover, the diversity of possible biomedical applications of the resulting nanoparticles was presented. This finding is important in terms of nanoparticle design for various biomedical applications and will reduce nanomedicines manufacturing time, along with difficulties related to comparative studies of magnetic nanoparticles with different magnetic core characteristics.https://www.mdpi.com/2079-4983/14/9/461magnetic nanoparticles3,4-dihydroxiphenylacetic acidnanotechnologyfunctional coatingsstabilizationsurface modification |
| spellingShingle | Alevtina Semkina Aleksey Nikitin Anna Ivanova Nelly Chmelyuk Natalia Sviridenkova Polina Lazareva Maxim Abakumov 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications Journal of Functional Biomaterials magnetic nanoparticles 3,4-dihydroxiphenylacetic acid nanotechnology functional coatings stabilization surface modification |
| title | 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications |
| title_full | 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications |
| title_fullStr | 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications |
| title_full_unstemmed | 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications |
| title_short | 3,4-Dihydroxiphenylacetic Acid-Based Universal Coating Technique for Magnetic Nanoparticles Stabilization for Biomedical Applications |
| title_sort | 3 4 dihydroxiphenylacetic acid based universal coating technique for magnetic nanoparticles stabilization for biomedical applications |
| topic | magnetic nanoparticles 3,4-dihydroxiphenylacetic acid nanotechnology functional coatings stabilization surface modification |
| url | https://www.mdpi.com/2079-4983/14/9/461 |
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