Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder
Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-04-01
|
| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/2/e101338.full |
| _version_ | 1826851740457107456 |
|---|---|
| author | Jie Wang Qing Xue Wenfeng Zhao Huang Wang Haixia Leng Mao Peng Xiukun Jin Liucen Tan Keming Gao Hongxing Wang Baoquan Min |
| author_facet | Jie Wang Qing Xue Wenfeng Zhao Huang Wang Haixia Leng Mao Peng Xiukun Jin Liucen Tan Keming Gao Hongxing Wang Baoquan Min |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms. |
| first_indexed | 2024-04-25T01:26:24Z |
| format | Article |
| id | doaj.art-0394284e970a45f8a64c77b127c5a684 |
| institution | Directory Open Access Journal |
| issn | 2517-729X |
| language | English |
| last_indexed | 2025-02-16T16:46:15Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj.art-0394284e970a45f8a64c77b127c5a6842025-01-29T13:45:09ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-04-0137210.1136/gpsych-2023-101338Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorderJie Wang0Qing Xue1Wenfeng Zhao2Huang Wang3Haixia Leng4Mao Peng5Xiukun Jin6Liucen Tan7Keming Gao8Hongxing Wang9Baoquan Min102 Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital Capital Medical University, Beijing, Chinaassociate professor3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China4 Electroconvulsive Therapy, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA1 Department of Rehabilitation Medicine, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China3 Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, ChinaBackground Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.https://gpsych.bmj.com/content/37/2/e101338.full |
| spellingShingle | Jie Wang Qing Xue Wenfeng Zhao Huang Wang Haixia Leng Mao Peng Xiukun Jin Liucen Tan Keming Gao Hongxing Wang Baoquan Min Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder General Psychiatry |
| title | Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder |
| title_full | Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder |
| title_fullStr | Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder |
| title_full_unstemmed | Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder |
| title_short | Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder |
| title_sort | brain wide activation involved in 15 ma transcranial alternating current stimulation in patients with first episode major depressive disorder |
| url | https://gpsych.bmj.com/content/37/2/e101338.full |
| work_keys_str_mv | AT jiewang brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT qingxue brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT wenfengzhao brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT huangwang brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT haixialeng brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT maopeng brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT xiukunjin brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT liucentan brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT keminggao brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT hongxingwang brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder AT baoquanmin brainwideactivationinvolvedin15matranscranialalternatingcurrentstimulationinpatientswithfirstepisodemajordepressivedisorder |