| Summary: | The new 4-amino-2-(<i>p</i>-tolyl)-7<i>H</i>-chromeno[5,6-<em>d</em>]oxazol-7-one was successfully prepared through the Au/TiO<sub>2</sub>-catalyzed NaBH<sub>4</sub> activation and chemoselective reduction of the new 4-nitro-2-(<i>p</i>-tolyl)-7<i>H</i>-chromeno[5,6-<em>d</em>]oxazol-7-one. The latter was synthesized by the one-pot tandem reactions of 6-hydroxy-5,7-dinitrocoumarin with <i>p</i>-tolylmethanol under Au/TiO<sub>2</sub> catalysis. The dinitrocoumarin was obtained by the nitration of 6-hydroxycoumarin with cerium ammonium nitrate (CAN). The structure of the synthesized compounds was confirmed by FT-IR, HR-MS, <sup>1</sup>H-NMR and <sup>13</sup>C-NMR analysis. Preliminary biological tests show low anti-lipid peroxidation activity for the title compound.
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