Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1986-03-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000100009&lng=en&tlng=en |
| _version_ | 1818554295505649664 |
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| author | Fausto Edmundo Lima Pereira Pedro Raso Paulo Marcos Zech Coelho |
| author_facet | Fausto Edmundo Lima Pereira Pedro Raso Paulo Marcos Zech Coelho |
| author_sort | Fausto Edmundo Lima Pereira |
| collection | DOAJ |
| description | Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut. |
| first_indexed | 2024-12-12T09:37:29Z |
| format | Article |
| id | doaj.art-0396de3b8dce4bedbc05b8132160b9c0 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T09:37:29Z |
| publishDate | 1986-03-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-0396de3b8dce4bedbc05b8132160b9c02022-12-22T00:28:40ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491986-03-01191394210.1590/S0037-86821986000100009S0037-86821986000100009Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoniFausto Edmundo Lima Pereira0Pedro Raso1Paulo Marcos Zech Coelho2Universidade Federal do Espírito SantoUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisMice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000100009&lng=en&tlng=enEsquistossomose experimentalSarcoma 180Esquistossomose e Câncer |
| spellingShingle | Fausto Edmundo Lima Pereira Pedro Raso Paulo Marcos Zech Coelho Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni Revista da Sociedade Brasileira de Medicina Tropical Esquistossomose experimental Sarcoma 180 Esquistossomose e Câncer |
| title | Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni |
| title_full | Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni |
| title_fullStr | Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni |
| title_full_unstemmed | Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni |
| title_short | Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni |
| title_sort | evolution of sarcoma 180 ascitic tumor in mice infected with schistosoma mansoni |
| topic | Esquistossomose experimental Sarcoma 180 Esquistossomose e Câncer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000100009&lng=en&tlng=en |
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