Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocy...
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10972 |
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| author | Yi Ding Qiulin Luo Hanyun Que Nan Wang Puyang Gong Jian Gu |
| author_facet | Yi Ding Qiulin Luo Hanyun Que Nan Wang Puyang Gong Jian Gu |
| author_sort | Yi Ding |
| collection | DOAJ |
| description | Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future. |
| first_indexed | 2024-03-09T23:41:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:41:29Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0398ec0adff749f0b394e98dd04fe87a2023-11-23T16:51:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181097210.3390/ijms231810972Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver DiseasesYi Ding0Qiulin Luo1Hanyun Que2Nan Wang3Puyang Gong4Jian Gu5College of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaCollege of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaCollege of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaCollege of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaCollege of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaCollege of Pharmacy, Southwest Minzu University, No. 16, South 4th Section, First Ring Road, Chengdu 610041, ChinaLiver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future.https://www.mdpi.com/1422-0067/23/18/10972mesenchymal stem cellsexosomesliver diseasestherapyregeneration |
| spellingShingle | Yi Ding Qiulin Luo Hanyun Que Nan Wang Puyang Gong Jian Gu Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases International Journal of Molecular Sciences mesenchymal stem cells exosomes liver diseases therapy regeneration |
| title | Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases |
| title_full | Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases |
| title_short | Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases |
| title_sort | mesenchymal stem cell derived exosomes a promising therapeutic agent for the treatment of liver diseases |
| topic | mesenchymal stem cells exosomes liver diseases therapy regeneration |
| url | https://www.mdpi.com/1422-0067/23/18/10972 |
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