Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache
ABSTRACT Introduction & objective: Migraine is the most common cause of headache. The aim of the present study was to evaluate the effects of topiramate (TPM) in the prevention of drug-resistant migraine headache. Materials & Methods: This is a double-blind clinical trial conducted on 70 p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2009-04-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-395&slc_lang=en&sid=1 |
| _version_ | 1811236347980021760 |
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| author | H Khani M Abedini A Zarvani A Azadmarzabadi A Roshanbakhash R Roshanbakhash A Ghorbani |
| author_facet | H Khani M Abedini A Zarvani A Azadmarzabadi A Roshanbakhash R Roshanbakhash A Ghorbani |
| author_sort | H Khani |
| collection | DOAJ |
| description | ABSTRACT
Introduction & objective: Migraine is the most common cause of headache. The aim of the present study was to evaluate the effects of topiramate (TPM) in the prevention of drug-resistant migraine headache.
Materials & Methods: This is a double-blind clinical trial conducted on 70 patients between ages 15 to 45 years referred to the Bu Ali Sina Hospital in Sari with a history of migraine attacks based on International Headache Society criteria for a period of more than one years with a minimum incidence of 1 to 6 attacks per month. The drug rate performance was assessed by response rate to treatment, mean changes in the number and severity of migraine attacks compared with the placebo group for 3 months. Collected data were analyzed using analysis of variance (ANOVA), Newman-Keuls and Spearman’s Coefficient Rank Correlation as the post hoc tests. GRAPHPAD software was used for analysis of the data.
Results: 66 of 70 patients completed the study. The mean age of the patients was 30.33±7.9 years. A significant reduction in the severity and frequency of migraine attacks was seen in all months (P < 0.0001) for topiramate treated group in compare to placebo group. Responder rate for patients treated with TPM was significantly higher than placebo group (63.6%, P<0.0001) in the 3rd month of the treatment Side effects of treatment were transient and well tolerated.
Conclusion: Low dose of TPM showed significant efficacy in prevention of migraine attacks within the first, second, and third month of treatment. Low dose of TPM seems to be a good therapeutic option for the patients with refractory migraine. |
| first_indexed | 2024-04-12T12:07:32Z |
| format | Article |
| id | doaj.art-03994ba3bbe146418e582de3b8951cbf |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-12T12:07:32Z |
| publishDate | 2009-04-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-03994ba3bbe146418e582de3b8951cbf2022-12-22T03:33:40ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142009-04-01141111Effects of Topiramate in the Prevention of Drug Resistant Migraine HeadacheH Khani0M Abedini1A Zarvani2A Azadmarzabadi3A Roshanbakhash4R Roshanbakhash5A Ghorbani6 ABSTRACT Introduction & objective: Migraine is the most common cause of headache. The aim of the present study was to evaluate the effects of topiramate (TPM) in the prevention of drug-resistant migraine headache. Materials & Methods: This is a double-blind clinical trial conducted on 70 patients between ages 15 to 45 years referred to the Bu Ali Sina Hospital in Sari with a history of migraine attacks based on International Headache Society criteria for a period of more than one years with a minimum incidence of 1 to 6 attacks per month. The drug rate performance was assessed by response rate to treatment, mean changes in the number and severity of migraine attacks compared with the placebo group for 3 months. Collected data were analyzed using analysis of variance (ANOVA), Newman-Keuls and Spearman’s Coefficient Rank Correlation as the post hoc tests. GRAPHPAD software was used for analysis of the data. Results: 66 of 70 patients completed the study. The mean age of the patients was 30.33±7.9 years. A significant reduction in the severity and frequency of migraine attacks was seen in all months (P < 0.0001) for topiramate treated group in compare to placebo group. Responder rate for patients treated with TPM was significantly higher than placebo group (63.6%, P<0.0001) in the 3rd month of the treatment Side effects of treatment were transient and well tolerated. Conclusion: Low dose of TPM showed significant efficacy in prevention of migraine attacks within the first, second, and third month of treatment. Low dose of TPM seems to be a good therapeutic option for the patients with refractory migraine.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-395&slc_lang=en&sid=1 |
| spellingShingle | H Khani M Abedini A Zarvani A Azadmarzabadi A Roshanbakhash R Roshanbakhash A Ghorbani Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache Armaghane Danesh Bimonthly Journal |
| title | Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache |
| title_full | Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache |
| title_fullStr | Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache |
| title_full_unstemmed | Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache |
| title_short | Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache |
| title_sort | effects of topiramate in the prevention of drug resistant migraine headache |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-395&slc_lang=en&sid=1 |
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