Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox
Obesity has long been considered to have a protective effect on bone, but specific complications in those with morbid obesity are known to have a detrimental impact on bone architecture. We aimed to study the bone microarchitecture (TBS—trabecular bone score) and bone mineral density (BMD) in postme...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/9/4/69 |
| _version_ | 1797502555888025600 |
|---|---|
| author | Antresa Jose Kripa Elizabeth Cherian Munaf Babajan Nandyal Stephen A. Jiwanmall Dheeraj Kattula Thomas V. Paul Nitin Kapoor |
| author_facet | Antresa Jose Kripa Elizabeth Cherian Munaf Babajan Nandyal Stephen A. Jiwanmall Dheeraj Kattula Thomas V. Paul Nitin Kapoor |
| author_sort | Antresa Jose |
| collection | DOAJ |
| description | Obesity has long been considered to have a protective effect on bone, but specific complications in those with morbid obesity are known to have a detrimental impact on bone architecture. We aimed to study the bone microarchitecture (TBS—trabecular bone score) and bone mineral density (BMD) in postmenopausal women with morbid obesity compared to obese and non-obese age-matched women. Eighty-five consecutive postmenopausal women with morbid obesity (body mass index (BMI) ≥ 35 kg/m<sup>2</sup>) were enrolled and compared to age-matched obese (<i>n</i> = 80) and non-obese postmenopausal controls (<i>n</i> = 85). The BMD and TBS were assessed in all subjects using a Hologic-QDR 4500-W Discovery-A DXA scanner. The mean BMD (gm/cm<sup>2</sup>) at the femoral neck in women with morbid obesity was found to be significantly lower as compared to the age-matched postmenopausal obese controls (0.723 versus 0.762, <i>p</i>-value = 0.002). The BMD at the lumbar spine and hip showed similar trends but were not statistically significant. The bone microarchitecture was found to be significantly lower in those with morbid obesity (1.205) as compared to the other two groups (obesity 1.244; non-obese 1.228) (<i>p</i> < 0.013). Though obesity was associated with a better bone density and bone microarchitecture in postmenopausal women, a paradoxical lower value was seen in those with morbid obesity. |
| first_indexed | 2024-03-10T03:35:47Z |
| format | Article |
| id | doaj.art-0399cb96a0cf4120b46cf8e4178ebfb9 |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-10T03:35:47Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-0399cb96a0cf4120b46cf8e4178ebfb92023-11-23T09:29:40ZengMDPI AGMedical Sciences2076-32712021-11-01946910.3390/medsci9040069Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical ParadoxAntresa Jose0Kripa Elizabeth Cherian1Munaf Babajan Nandyal2Stephen A. Jiwanmall3Dheeraj Kattula4Thomas V. Paul5Nitin Kapoor6Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, IndiaDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, IndiaDepartment of Psychiatry, Christian Medical College, Vellore 632004, IndiaDepartment of Psychiatry, Christian Medical College, Vellore 632004, IndiaDepartment of Psychiatry, Christian Medical College, Vellore 632004, IndiaDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, IndiaDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, IndiaObesity has long been considered to have a protective effect on bone, but specific complications in those with morbid obesity are known to have a detrimental impact on bone architecture. We aimed to study the bone microarchitecture (TBS—trabecular bone score) and bone mineral density (BMD) in postmenopausal women with morbid obesity compared to obese and non-obese age-matched women. Eighty-five consecutive postmenopausal women with morbid obesity (body mass index (BMI) ≥ 35 kg/m<sup>2</sup>) were enrolled and compared to age-matched obese (<i>n</i> = 80) and non-obese postmenopausal controls (<i>n</i> = 85). The BMD and TBS were assessed in all subjects using a Hologic-QDR 4500-W Discovery-A DXA scanner. The mean BMD (gm/cm<sup>2</sup>) at the femoral neck in women with morbid obesity was found to be significantly lower as compared to the age-matched postmenopausal obese controls (0.723 versus 0.762, <i>p</i>-value = 0.002). The BMD at the lumbar spine and hip showed similar trends but were not statistically significant. The bone microarchitecture was found to be significantly lower in those with morbid obesity (1.205) as compared to the other two groups (obesity 1.244; non-obese 1.228) (<i>p</i> < 0.013). Though obesity was associated with a better bone density and bone microarchitecture in postmenopausal women, a paradoxical lower value was seen in those with morbid obesity.https://www.mdpi.com/2076-3271/9/4/69morbid obesitySouth Asian phenotypebone obesity paradoxosteoporosis |
| spellingShingle | Antresa Jose Kripa Elizabeth Cherian Munaf Babajan Nandyal Stephen A. Jiwanmall Dheeraj Kattula Thomas V. Paul Nitin Kapoor Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox Medical Sciences morbid obesity South Asian phenotype bone obesity paradox osteoporosis |
| title | Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox |
| title_full | Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox |
| title_fullStr | Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox |
| title_full_unstemmed | Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox |
| title_short | Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox |
| title_sort | trabecular bone score and bone mineral density in postmenopausal women with morbid obesity a clinical paradox |
| topic | morbid obesity South Asian phenotype bone obesity paradox osteoporosis |
| url | https://www.mdpi.com/2076-3271/9/4/69 |
| work_keys_str_mv | AT antresajose trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT kripaelizabethcherian trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT munafbabajannandyal trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT stephenajiwanmall trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT dheerajkattula trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT thomasvpaul trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox AT nitinkapoor trabecularbonescoreandbonemineraldensityinpostmenopausalwomenwithmorbidobesityaclinicalparadox |