Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases
Exosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/8/766 |
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| author | Emanuela Diomaiuto Valeria Principe Adriana De Luca Flaviana Laperuta Chiara Alterisio Antonio Di Loria |
| author_facet | Emanuela Diomaiuto Valeria Principe Adriana De Luca Flaviana Laperuta Chiara Alterisio Antonio Di Loria |
| author_sort | Emanuela Diomaiuto |
| collection | DOAJ |
| description | Exosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA, and DNA), and lipids. Exosomes represent a potentially accurate footprint of the miRNA profile of the parental cell and can therefore be proposed as potential and sensitive biomarkers, both in diagnosing and monitoring a variety of diseases in humans and animals. Liquid biopsy offers itself as a non-invasive or minimally invasive, pain-free, time-saving alternative to conventional tissue biopsy. Exosomes in both human and veterinary medicine find their major application in neoplastic diseases, but applications in the field of veterinary cardiology, nephrology, reproduction, parasitology, and regenerative medicine are currently being explored. Exosomes can therefore be used as diagnostic, prognostic, and, in some cases, therapeutic tools for several conditions. The aim of this review was to assess the current applications of exosomes in veterinary medicine, particularly in dog and cat patients. |
| first_indexed | 2024-03-10T08:28:53Z |
| format | Article |
| id | doaj.art-039dc954501f49a785090d4506d316c6 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T08:28:53Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-039dc954501f49a785090d4506d316c62023-11-22T09:11:30ZengMDPI AGPharmaceuticals1424-82472021-08-0114876610.3390/ph14080766Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic DiseasesEmanuela Diomaiuto0Valeria Principe1Adriana De Luca2Flaviana Laperuta3Chiara Alterisio4Antonio Di Loria5Department of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Productions, University Federico II of Napoli, Via F. Delpino 1, 80137 Napoli, ItalyExosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA, and DNA), and lipids. Exosomes represent a potentially accurate footprint of the miRNA profile of the parental cell and can therefore be proposed as potential and sensitive biomarkers, both in diagnosing and monitoring a variety of diseases in humans and animals. Liquid biopsy offers itself as a non-invasive or minimally invasive, pain-free, time-saving alternative to conventional tissue biopsy. Exosomes in both human and veterinary medicine find their major application in neoplastic diseases, but applications in the field of veterinary cardiology, nephrology, reproduction, parasitology, and regenerative medicine are currently being explored. Exosomes can therefore be used as diagnostic, prognostic, and, in some cases, therapeutic tools for several conditions. The aim of this review was to assess the current applications of exosomes in veterinary medicine, particularly in dog and cat patients.https://www.mdpi.com/1424-8247/14/8/766exosomesextracellular vesiclesmiRNAveterinary medicinedogcat |
| spellingShingle | Emanuela Diomaiuto Valeria Principe Adriana De Luca Flaviana Laperuta Chiara Alterisio Antonio Di Loria Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases Pharmaceuticals exosomes extracellular vesicles miRNA veterinary medicine dog cat |
| title | Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases |
| title_full | Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases |
| title_fullStr | Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases |
| title_full_unstemmed | Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases |
| title_short | Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases |
| title_sort | exosomes in dogs and cats an innovative approach to neoplastic and non neoplastic diseases |
| topic | exosomes extracellular vesicles miRNA veterinary medicine dog cat |
| url | https://www.mdpi.com/1424-8247/14/8/766 |
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