Quantifying β-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells

Quantifying β-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells

Signal propagation from the cell membrane to a promoter can induce gene expression. To examine signal transmission through sub-cellular compartments and its effect on transcription levels in individual cells within a population, we used the Wnt/β-catenin signaling pathway as a model system. Wnt sign...

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Bibliographic Details
Main Authors: Pinhas Kafri, Sarah E Hasenson, Itamar Kanter, Jonathan Sheinberger, Noa Kinor, Sharon Yunger, Yaron Shav-Tal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
transcription
signalling
transcription factor dynamics
live-cell imaging
transcriptional kinetics
Online Access:https://elifesciences.org/articles/16748

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