IL18 signaling promotes homing of mature Tregs into the thymus

IL18 signaling promotes homing of mature Tregs into the thymus

Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitute a major subset of yet poorly understood cells....

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Bibliographic Details
Main Authors: Cristina Peligero-Cruz, Tal Givony, Arnau Sebé-Pedrós, Jan Dobeš, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
thymus
Tregs
IL18R
CCR6
migration
recirculation
Online Access:https://elifesciences.org/articles/58213

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