Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach
Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules such as chemokines, and cytokines, cell adhesion molecules, lipid mediators, interleukins (IL), growth factors (GFs), hormones, micro RNA...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2020-03-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/49413/download/pdf/ |
| _version_ | 1797425447968964608 |
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| author | Liubov A. Pokrovskaya Ekaterina V. Zubareva Sergey V. Nadezhdin Anna S. Lysenko Tatyana L. Litovkina |
| author_facet | Liubov A. Pokrovskaya Ekaterina V. Zubareva Sergey V. Nadezhdin Anna S. Lysenko Tatyana L. Litovkina |
| author_sort | Liubov A. Pokrovskaya |
| collection | DOAJ |
| description | Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules such as chemokines, and cytokines, cell adhesion molecules, lipid mediators, interleukins (IL), growth factors (GFs), hormones, micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), exosomes, as well as microvesicles, the secretome. MSCs of various origin, including adipose-derived stem cells (ASCs), bone marrow derived mesenchymal stem cells (BM-MSCs), human uterine cervical stem cells (hUCESCs), may be good candidates for obtaining secretome-derived products. Different population of MSCs can secret different factors which could have anti-inflammatory, anti-apoptotic, anti-fibrotic activities, a neuroprotective effect, could improve bone, muscle, liver regeneration and wound healing. Therefore, the paracrine activity of conditioned medium obtained when cultivating MSCs, due to a plethora of bioactive factors, was assumed to have the most prominent cell-free therapeutic impact and can serve as a better option in the field of regenerative medicine in future. |
| first_indexed | 2024-03-09T08:16:16Z |
| format | Article |
| id | doaj.art-03a022f238714683a41ea6b764d207e1 |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T08:16:16Z |
| publishDate | 2020-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-03a022f238714683a41ea6b764d207e12023-12-02T22:03:15ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2020-03-0161576810.3897/rrpharmacology.6.4941349413Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approachLiubov A. Pokrovskaya0Ekaterina V. Zubareva1Sergey V. Nadezhdin2Anna S. Lysenko3Tatyana L. Litovkina4National Research Tomsk State UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityMesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules such as chemokines, and cytokines, cell adhesion molecules, lipid mediators, interleukins (IL), growth factors (GFs), hormones, micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), exosomes, as well as microvesicles, the secretome. MSCs of various origin, including adipose-derived stem cells (ASCs), bone marrow derived mesenchymal stem cells (BM-MSCs), human uterine cervical stem cells (hUCESCs), may be good candidates for obtaining secretome-derived products. Different population of MSCs can secret different factors which could have anti-inflammatory, anti-apoptotic, anti-fibrotic activities, a neuroprotective effect, could improve bone, muscle, liver regeneration and wound healing. Therefore, the paracrine activity of conditioned medium obtained when cultivating MSCs, due to a plethora of bioactive factors, was assumed to have the most prominent cell-free therapeutic impact and can serve as a better option in the field of regenerative medicine in future.https://rrpharmacology.pensoft.net/article/49413/download/pdf/ |
| spellingShingle | Liubov A. Pokrovskaya Ekaterina V. Zubareva Sergey V. Nadezhdin Anna S. Lysenko Tatyana L. Litovkina Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach Research Results in Pharmacology |
| title | Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach |
| title_full | Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach |
| title_fullStr | Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach |
| title_full_unstemmed | Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach |
| title_short | Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach |
| title_sort | biological activity of mesenchymal stem cells secretome as a basis for cell free therapeutic approach |
| url | https://rrpharmacology.pensoft.net/article/49413/download/pdf/ |
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