Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls
Background: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315821930213X |
| _version_ | 1818962002098257920 |
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| author | Inka Ristow Jens Foell Christian Kärgel Viola Borchardt Shijia Li Dominik Denzel Joachim Witzel Krasimira Drumkova Klaus Beier Tillmann H.C. Kruger Jorge Ponseti Boris Schiffer Kolja Schiltz Henrik Walter Martin Walter |
| author_facet | Inka Ristow Jens Foell Christian Kärgel Viola Borchardt Shijia Li Dominik Denzel Joachim Witzel Krasimira Drumkova Klaus Beier Tillmann H.C. Kruger Jorge Ponseti Boris Schiffer Kolja Schiltz Henrik Walter Martin Walter |
| author_sort | Inka Ristow |
| collection | DOAJ |
| description | Background: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred) sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation. Methods: Two fMRI studies (1.5 and 7 Tesla) were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls) to assess brain activity during expectancy of subsequent adult (non-preferred) sexual stimuli. In the second study (7 Tesla) additionally child (preferred) cues were presented. Results: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC) activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation. Conclusion: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented. Keywords: Dorsal anterior cingulate cortex (dACC), Expectancy, fMRI, Pedophilic sex offenders, Pedophilic disorder, Sexual processing |
| first_indexed | 2024-12-20T12:22:23Z |
| format | Article |
| id | doaj.art-03a041ef9b634736ad65ad5143a1d98e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-20T12:22:23Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-03a041ef9b634736ad65ad5143a1d98e2022-12-21T19:40:56ZengElsevierNeuroImage: Clinical2213-15822019-01-0123Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controlsInka Ristow0Jens Foell1Christian Kärgel2Viola Borchardt3Shijia Li4Dominik Denzel5Joachim Witzel6Krasimira Drumkova7Klaus Beier8Tillmann H.C. Kruger9Jorge Ponseti10Boris Schiffer11Kolja Schiltz12Henrik Walter13Martin Walter14Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany; Leibniz Institute for Neurobiology, Department for Behavioral Neurology, Magdeburg, GermanyDepartment of Psychology, Florida State University, Tallahassee, FL, USADivision of Forensic Psychiatry, LWL-University Hospital, Ruhr University Bochum, Bochum, GermanyClinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany; Leibniz Institute for Neurobiology, Department for Behavioral Neurology, Magdeburg, GermanyKey Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, ChinaClinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany; Leibniz Institute for Neurobiology, Department for Behavioral Neurology, Magdeburg, GermanyForensic Psychiatric State Hospital of Saxony-Anhalt, Stendal-Uchtspringe, GermanyForensic Psychiatric State Hospital of Saxony-Anhalt, Stendal-Uchtspringe, GermanyInstitute of Sexology and Sexual Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology and Sexual Medicine, Hannover Medical School, Hannover, GermanyInstitute of Sexual Medicine and Forensic Psychiatry and Psychotherapy, Kiel University, Medical School, Kiel, GermanyDivision of Forensic Psychiatry, LWL-University Hospital, Ruhr University Bochum, Bochum, GermanySection of Forensic Psychiatry, Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany; Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Magdeburg, GermanyDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Univesität zu Berlin and Berlin Institute of Health, Berlin, GermanyClinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany; Leibniz Institute for Neurobiology, Department for Behavioral Neurology, Magdeburg, Germany; Department of Psychiatry and Psychotherapy, Otto von Guericke University of Magdeburg, Magdeburg, Germany; Department of Psychiatry, Eberhard Karls University, Tübingen, Germany; Max Planck Institute for Biological Cybernetics Tübingen, Germany; Corresponding author at: Head Section for Translational Psychiatry, Dept. of Psychiatry, University of Tuebingen, Osianderstr. 24, 72076 Tübingen, Germany.Background: Pedophilic disorder is characterized by increased sexual interest towards children, with comparatively lesser interest towards adults. In real life, the behavior of subjects with pedophilic disorder is shaped by evaluative processes in response to sexually relevant cues. Therefore, brain activation during anticipation of sexually relevant cues is of potential interest. Whereas previous research demonstrated reduced activation when viewing adult (non-preferred) sexual stimuli in pedophilic sex offenders (PSOs), it is not known if anticipation of preferred versus unpreferred stimuli will elicit differential brain activation. Methods: Two fMRI studies (1.5 and 7 Tesla) were conducted in separate samples, each with 26 subjects (13/13 PSOs/controls) to assess brain activity during expectancy of subsequent adult (non-preferred) sexual stimuli. In the second study (7 Tesla) additionally child (preferred) cues were presented. Results: As predicted, expectancy of adult sexual stimuli generated smaller dorsal anterior cingulate cortex (dACC) activation in PSOs in both studies, driven by stronger activation during expectancy of adult erotic stimuli in non-pedophilic controls (HCs). In the second study, PSOs showed significantly increased activations in dACC during expectancy of child stimuli compared with expectancy of adult stimuli. This difference was significantly greater compared to the same contrast in HCs, thus demonstrating preference specificity of dACC activation. Conclusion: Our findings support the notion of decreased brain activation to adult cues in PSOs and preference specificity in neural response during expectancy of erotic stimuli. The localization of these cue reactivity differences in the salience network supports the interpretation that PSOs show abnormally increased preparatory activation even before relevant sexual stimuli are actually presented. Keywords: Dorsal anterior cingulate cortex (dACC), Expectancy, fMRI, Pedophilic sex offenders, Pedophilic disorder, Sexual processinghttp://www.sciencedirect.com/science/article/pii/S221315821930213X |
| spellingShingle | Inka Ristow Jens Foell Christian Kärgel Viola Borchardt Shijia Li Dominik Denzel Joachim Witzel Krasimira Drumkova Klaus Beier Tillmann H.C. Kruger Jorge Ponseti Boris Schiffer Kolja Schiltz Henrik Walter Martin Walter Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls NeuroImage: Clinical |
| title | Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| title_full | Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| title_fullStr | Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| title_full_unstemmed | Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| title_short | Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| title_sort | expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls |
| url | http://www.sciencedirect.com/science/article/pii/S221315821930213X |
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