Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study)
Abstract The hierarchical design of the toe pad surface in geckos and its reversible adhesiveness have inspired material scientists for many years. Micro‐ and nano‐patterned surfaces with impressive adhesive performance have been developed to mimic gecko's properties. While the adhesive perform...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202303816 |
| _version_ | 1797263437336674304 |
|---|---|
| author | Jennifer Y. Kasper Matthias W. Laschke Marcus Koch Lorenzo Alibardi Thomas Magin Carien M. Niessen Aránzazu del Campo |
| author_facet | Jennifer Y. Kasper Matthias W. Laschke Marcus Koch Lorenzo Alibardi Thomas Magin Carien M. Niessen Aránzazu del Campo |
| author_sort | Jennifer Y. Kasper |
| collection | DOAJ |
| description | Abstract The hierarchical design of the toe pad surface in geckos and its reversible adhesiveness have inspired material scientists for many years. Micro‐ and nano‐patterned surfaces with impressive adhesive performance have been developed to mimic gecko's properties. While the adhesive performance achieved in some examples has surpassed living counterparts, the durability of the fabricated surfaces is limited and the capability to self‐renew and restore function—inherent to biological systems—is unimaginable. Here the morphogenesis of gecko setae using skin samples from the Bibron´s gecko (Chondrodactylus bibronii) is studied. Gecko setae develop as specialized apical differentiation structures at a distinct cell–cell layer interface within the skin epidermis. A primary role for F‐actin and microtubules as templating structural elements is necessary for the development of setae's hierarchical morphology, and a stabilization role of keratins and corneus beta proteins is identified. Setae grow from single cells in a bottom layer protruding into four neighboring cells in the upper layer. The resulting multicellular junction can play a role during shedding by facilitating fracture of the cell–cell interface and release of the high aspect ratio setae. The results contribute to the understanding of setae regeneration and may inspire future concepts to bioengineer self‐renewable patterned adhesive surfaces. |
| first_indexed | 2024-04-25T00:12:59Z |
| format | Article |
| id | doaj.art-03a2776169804ddcb2118ef016e5e7ff |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-25T00:12:59Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-03a2776169804ddcb2118ef016e5e7ff2024-03-13T07:30:35ZengWileyAdvanced Science2198-38442024-03-011110n/an/a10.1002/advs.202303816Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study)Jennifer Y. Kasper0Matthias W. Laschke1Marcus Koch2Lorenzo Alibardi3Thomas Magin4Carien M. Niessen5Aránzazu del Campo6INM‐Leibniz Institute for New Materials Campus D2 2 66123 Saarbruecken GermanyInstitute for Clinical and Experimental Surgery Saarland University 66421 Homburg GermanyINM‐Leibniz Institute for New Materials Campus D2 2 66123 Saarbruecken GermanyComparative Anatomy Department of Biology University of Bologna & Comparative Histolab 40126 Bologna ItalyDivision of Cell and Developmental Biology Institute of Biology Leipzig University 04103 Leipzig GermanyDepartment Cell Biology of the Skin Cologne Excellence Cluster for Stress Responses in Ageing‐associated diseases (CECAD) Center for Molecular Medicine Cologne (CMMC) University Hospital Cologne University of Cologne 50931 Cologne GermanyINM‐Leibniz Institute for New Materials Campus D2 2 66123 Saarbruecken GermanyAbstract The hierarchical design of the toe pad surface in geckos and its reversible adhesiveness have inspired material scientists for many years. Micro‐ and nano‐patterned surfaces with impressive adhesive performance have been developed to mimic gecko's properties. While the adhesive performance achieved in some examples has surpassed living counterparts, the durability of the fabricated surfaces is limited and the capability to self‐renew and restore function—inherent to biological systems—is unimaginable. Here the morphogenesis of gecko setae using skin samples from the Bibron´s gecko (Chondrodactylus bibronii) is studied. Gecko setae develop as specialized apical differentiation structures at a distinct cell–cell layer interface within the skin epidermis. A primary role for F‐actin and microtubules as templating structural elements is necessary for the development of setae's hierarchical morphology, and a stabilization role of keratins and corneus beta proteins is identified. Setae grow from single cells in a bottom layer protruding into four neighboring cells in the upper layer. The resulting multicellular junction can play a role during shedding by facilitating fracture of the cell–cell interface and release of the high aspect ratio setae. The results contribute to the understanding of setae regeneration and may inspire future concepts to bioengineer self‐renewable patterned adhesive surfaces.https://doi.org/10.1002/advs.202303816actin assemblyapical topographiescornified tissuegecko‐inspired adhesiveskeratin assemblysetae |
| spellingShingle | Jennifer Y. Kasper Matthias W. Laschke Marcus Koch Lorenzo Alibardi Thomas Magin Carien M. Niessen Aránzazu del Campo Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) Advanced Science actin assembly apical topographies cornified tissue gecko‐inspired adhesives keratin assembly setae |
| title | Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) |
| title_full | Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) |
| title_fullStr | Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) |
| title_full_unstemmed | Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) |
| title_short | Actin‐templated Structures: Nature's Way to Hierarchical Surface Patterns (Gecko's Setae as Case Study) |
| title_sort | actin templated structures nature s way to hierarchical surface patterns gecko s setae as case study |
| topic | actin assembly apical topographies cornified tissue gecko‐inspired adhesives keratin assembly setae |
| url | https://doi.org/10.1002/advs.202303816 |
| work_keys_str_mv | AT jenniferykasper actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT matthiaswlaschke actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT marcuskoch actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT lorenzoalibardi actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT thomasmagin actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT carienmniessen actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy AT aranzazudelcampo actintemplatedstructuresnatureswaytohierarchicalsurfacepatternsgeckossetaeascasestudy |