Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis
Objective: Our previous studies found that angiotensin-(1–7) (Ang-(1–7)) is an endogenous counter-factor of angiotensin II (Ang-II). However, the balance between Ang-II and Ang-(1–7) in the development of human coronary atherosclerosis is not determined. Methods and results: The plasma levels of Ang...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2016-07-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320316659618 |
| _version_ | 1797283007995838464 |
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| author | Wenjing Li Jifu Li Panpan Hao Wenqiang Chen Xiao Meng Hongxuan Li Yun Zhang Cheng Zhang Jianmin Yang |
| author_facet | Wenjing Li Jifu Li Panpan Hao Wenqiang Chen Xiao Meng Hongxuan Li Yun Zhang Cheng Zhang Jianmin Yang |
| author_sort | Wenjing Li |
| collection | DOAJ |
| description | Objective: Our previous studies found that angiotensin-(1–7) (Ang-(1–7)) is an endogenous counter-factor of angiotensin II (Ang-II). However, the balance between Ang-II and Ang-(1–7) in the development of human coronary atherosclerosis is not determined. Methods and results: The plasma levels of Ang-II and Ang-(1–7) were detected by enzyme-linked immunosorbent assay (ELISA) in 112 patients with known or suspected coronary artery disease (CAD) undergoing coronary angiography. Patients were divided into three groups based on the coronary angiography as follows: (1) normal ( n = 13); (2) noncritical CAD (<50% stenosis, n = 17); and (3) critical CAD (⩾50% stenosis, n = 82). The plasma levels of Ang-II, Ang-(1–7) and the ratio of Ang-II and Ang-(1–7) (Ang-II/Ang-(1–7) were comparable between the normal and noncritical CAD groups. However, Ang-II, Ang-(1–7), and especially Ang-II/Ang-(1–7), were elevated in patients with critical CAD, compared with patients with normal or noncritical CAD. The level of Ang-II/Ang-(1–7) was positively associated with serious coronary stenosis, and correlated with tumor necrosis factor-alpha (TNF-α) level. Conclusion: Both Ang-II and Ang-(1–7) expression are significantly increased in patients with critical CAD. However, increased Ang-II/Ang-(1–7) ratios may lead to Ang-II over-activation and aggravate atherosclerosis progression. |
| first_indexed | 2024-03-07T17:21:44Z |
| format | Article |
| id | doaj.art-03a4c47d062e4ab39a9d95601c6058be |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:21:44Z |
| publishDate | 2016-07-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-03a4c47d062e4ab39a9d95601c6058be2024-03-02T19:37:06ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762016-07-011710.1177/1470320316659618Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosisWenjing Li0Jifu Li1Panpan Hao2Wenqiang Chen3Xiao Meng4Hongxuan Li5Yun Zhang6Cheng Zhang7Jianmin Yang8Fine Arts School of Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. ChinaObjective: Our previous studies found that angiotensin-(1–7) (Ang-(1–7)) is an endogenous counter-factor of angiotensin II (Ang-II). However, the balance between Ang-II and Ang-(1–7) in the development of human coronary atherosclerosis is not determined. Methods and results: The plasma levels of Ang-II and Ang-(1–7) were detected by enzyme-linked immunosorbent assay (ELISA) in 112 patients with known or suspected coronary artery disease (CAD) undergoing coronary angiography. Patients were divided into three groups based on the coronary angiography as follows: (1) normal ( n = 13); (2) noncritical CAD (<50% stenosis, n = 17); and (3) critical CAD (⩾50% stenosis, n = 82). The plasma levels of Ang-II, Ang-(1–7) and the ratio of Ang-II and Ang-(1–7) (Ang-II/Ang-(1–7) were comparable between the normal and noncritical CAD groups. However, Ang-II, Ang-(1–7), and especially Ang-II/Ang-(1–7), were elevated in patients with critical CAD, compared with patients with normal or noncritical CAD. The level of Ang-II/Ang-(1–7) was positively associated with serious coronary stenosis, and correlated with tumor necrosis factor-alpha (TNF-α) level. Conclusion: Both Ang-II and Ang-(1–7) expression are significantly increased in patients with critical CAD. However, increased Ang-II/Ang-(1–7) ratios may lead to Ang-II over-activation and aggravate atherosclerosis progression.https://doi.org/10.1177/1470320316659618 |
| spellingShingle | Wenjing Li Jifu Li Panpan Hao Wenqiang Chen Xiao Meng Hongxuan Li Yun Zhang Cheng Zhang Jianmin Yang Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis Journal of the Renin-Angiotensin-Aldosterone System |
| title | Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis |
| title_full | Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis |
| title_fullStr | Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis |
| title_full_unstemmed | Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis |
| title_short | Imbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis |
| title_sort | imbalance between angiotensin ii and angiotensin 1 7 in human coronary atherosclerosis |
| url | https://doi.org/10.1177/1470320316659618 |
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