Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
Introduction We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. Case presentation A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-09-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12179 |
| _version_ | 1818134724359487488 |
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| author | Mizuki Hisano Renpei Kato Hiroaki Itamochi Tomohiko Matsuura Shigekatsu Maekawa Yoichiro Kato Mitsugu Kanehira Ryo Takata Tsukasa Baba Wataru Obara |
| author_facet | Mizuki Hisano Renpei Kato Hiroaki Itamochi Tomohiko Matsuura Shigekatsu Maekawa Yoichiro Kato Mitsugu Kanehira Ryo Takata Tsukasa Baba Wataru Obara |
| author_sort | Mizuki Hisano |
| collection | DOAJ |
| description | Introduction We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. Case presentation A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 months after simultaneous radical nephrectomy and hysterectomy with vaginal resection. Despite the treatment with sunitinib and nivolumab, the patient died 7 months after surgery. Immunohistochemical staining of primary and metastatic tumor specimens was CD8 and programmed death ligand‐1 negative. Conclusion Although vaginal metastasis of renal cell carcinoma is rare, lack of CD8 and programmed death ligand‐1 expression may cause nivolumab resistance and may be useful markers in patients with metastatic renal cell carcinoma. |
| first_indexed | 2024-12-11T09:13:10Z |
| format | Article |
| id | doaj.art-03a4fd061ef9497cbca93760787fc261 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-12-11T09:13:10Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-03a4fd061ef9497cbca93760787fc2612022-12-22T01:13:27ZengWileyIJU Case Reports2577-171X2020-09-013518518810.1002/iju5.12179Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasisMizuki Hisano0Renpei Kato1Hiroaki Itamochi2Tomohiko Matsuura3Shigekatsu Maekawa4Yoichiro Kato5Mitsugu Kanehira6Ryo Takata7Tsukasa Baba8Wataru Obara9Departments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartment Obstetrics and Gynecology Iwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanDepartment Obstetrics and Gynecology Iwate Medical University School of Medicine Yahaba JapanDepartments of UrologyIwate Medical University School of Medicine Yahaba JapanIntroduction We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. Case presentation A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 months after simultaneous radical nephrectomy and hysterectomy with vaginal resection. Despite the treatment with sunitinib and nivolumab, the patient died 7 months after surgery. Immunohistochemical staining of primary and metastatic tumor specimens was CD8 and programmed death ligand‐1 negative. Conclusion Although vaginal metastasis of renal cell carcinoma is rare, lack of CD8 and programmed death ligand‐1 expression may cause nivolumab resistance and may be useful markers in patients with metastatic renal cell carcinoma.https://doi.org/10.1002/iju5.12179CD8PD‐L1immune checkpoint inhibitorrenal cell carcinomavaginal metastasis |
| spellingShingle | Mizuki Hisano Renpei Kato Hiroaki Itamochi Tomohiko Matsuura Shigekatsu Maekawa Yoichiro Kato Mitsugu Kanehira Ryo Takata Tsukasa Baba Wataru Obara Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis IJU Case Reports CD8 PD‐L1 immune checkpoint inhibitor renal cell carcinoma vaginal metastasis |
| title | Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| title_full | Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| title_fullStr | Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| title_full_unstemmed | Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| title_short | Rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| title_sort | rapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis |
| topic | CD8 PD‐L1 immune checkpoint inhibitor renal cell carcinoma vaginal metastasis |
| url | https://doi.org/10.1002/iju5.12179 |
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