VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma
Abstract Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis. Methods Serum levels of alpha-fetoprotein, des-γ-carboxy prothrombin, Lens culinaris agglutinin-reactive fraction of alpha-fetop...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-10-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-019-1082-1 |
| _version_ | 1811223415720247296 |
|---|---|
| author | Hiroaki Takaya Tadashi Namisaki Mitsuteru Kitade Kosuke Kaji Keisuke Nakanishi Yuki Tsuji Naotaka Shimozato Kei Moriya Kenichiro Seki Yasuhiko Sawada Soichiro Saikawa Shinya Sato Hideto Kawaratani Takemi Akahane Ryuichi Noguchi Masanori Matsumoto Hitoshi Yoshiji |
| author_facet | Hiroaki Takaya Tadashi Namisaki Mitsuteru Kitade Kosuke Kaji Keisuke Nakanishi Yuki Tsuji Naotaka Shimozato Kei Moriya Kenichiro Seki Yasuhiko Sawada Soichiro Saikawa Shinya Sato Hideto Kawaratani Takemi Akahane Ryuichi Noguchi Masanori Matsumoto Hitoshi Yoshiji |
| author_sort | Hiroaki Takaya |
| collection | DOAJ |
| description | Abstract Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis. Methods Serum levels of alpha-fetoprotein, des-γ-carboxy prothrombin, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (alpha-fetoprotein-L3%), vascular endothelial growth factor, and vascular endothelial growth factor receptor-2, as well as the plasma levels of von Willebrand factor antigen (von Willebrand factor: Ag) and ADAMTS13 activity (ADAMTS13:AC), were evaluated in 41 cirrhotic patients with HCC undergoing radiofrequency ablation and in 20 cirrhotic patients without HCC. The diagnostic accuracy of each biomarker was evaluated using the receiver operating characteristic curve analysis. Results The von Willebrand factor: Ag and von Willebrand factor: Ag/ADAMTS13:AC ratios were significantly higher in cirrhotic patients with HCC than in those without HCC (p < 0.05 and p < 0.01, respectively), whereas ADAMTS13:AC was significantly lower in those with HCC than those without HCC (p < 0.05). However, no relationship was observed between the von Willebrand factor: Ag/ADAMTS13:AC ratio and serum tumor markers such as alpha-fetoprotein, des-γ-carboxy prothrombin, and alpha-fetoprotein-L3%. Multivariate regression analysis identified von Willebrand factor: Ag/ADAMTS13:AC ratio and alpha-fetoprotein-L3% as significant factors of HCC development. Receiver operating characteristic analysis showed that the von Willebrand factor: Ag/ADAMTS13:AC ratio and alpha-fetoprotein-L3% had a better performance than alpha-fetoprotein, des-γ-carboxy prothrombin, alpha-fetoprotein-L3%, vascular endothelial growth factor, and vascular endothelial growth factor receptor-2, von Willebrand factor: Ag, and ADAMTS13:AC. The von Willebrand factor: Ag/ADAMTS13:AC ratio was exclusively correlated with tumor volume and stage as well as serum vascular endothelial growth factor levels. Conclusions The von Willebrand factor: Ag/ADAMTS13:AC ratio can potentially serve as a novel biomarker for early diagnosis of HCC in cirrhotic patients. |
| first_indexed | 2024-04-12T08:32:33Z |
| format | Article |
| id | doaj.art-03a5e514da2741f9a13e754337c31019 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T08:32:33Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-03a5e514da2741f9a13e754337c310192022-12-22T03:40:07ZengBMCBMC Gastroenterology1471-230X2019-10-0119111010.1186/s12876-019-1082-1VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinomaHiroaki Takaya0Tadashi Namisaki1Mitsuteru Kitade2Kosuke Kaji3Keisuke Nakanishi4Yuki Tsuji5Naotaka Shimozato6Kei Moriya7Kenichiro Seki8Yasuhiko Sawada9Soichiro Saikawa10Shinya Sato11Hideto Kawaratani12Takemi Akahane13Ryuichi Noguchi14Masanori Matsumoto15Hitoshi Yoshiji16Third Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityDepartment of Blood Transfusion Medicine, Nara Medical UniversityThird Department of Internal Medicine, Nara Medical UniversityAbstract Background To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis. Methods Serum levels of alpha-fetoprotein, des-γ-carboxy prothrombin, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (alpha-fetoprotein-L3%), vascular endothelial growth factor, and vascular endothelial growth factor receptor-2, as well as the plasma levels of von Willebrand factor antigen (von Willebrand factor: Ag) and ADAMTS13 activity (ADAMTS13:AC), were evaluated in 41 cirrhotic patients with HCC undergoing radiofrequency ablation and in 20 cirrhotic patients without HCC. The diagnostic accuracy of each biomarker was evaluated using the receiver operating characteristic curve analysis. Results The von Willebrand factor: Ag and von Willebrand factor: Ag/ADAMTS13:AC ratios were significantly higher in cirrhotic patients with HCC than in those without HCC (p < 0.05 and p < 0.01, respectively), whereas ADAMTS13:AC was significantly lower in those with HCC than those without HCC (p < 0.05). However, no relationship was observed between the von Willebrand factor: Ag/ADAMTS13:AC ratio and serum tumor markers such as alpha-fetoprotein, des-γ-carboxy prothrombin, and alpha-fetoprotein-L3%. Multivariate regression analysis identified von Willebrand factor: Ag/ADAMTS13:AC ratio and alpha-fetoprotein-L3% as significant factors of HCC development. Receiver operating characteristic analysis showed that the von Willebrand factor: Ag/ADAMTS13:AC ratio and alpha-fetoprotein-L3% had a better performance than alpha-fetoprotein, des-γ-carboxy prothrombin, alpha-fetoprotein-L3%, vascular endothelial growth factor, and vascular endothelial growth factor receptor-2, von Willebrand factor: Ag, and ADAMTS13:AC. The von Willebrand factor: Ag/ADAMTS13:AC ratio was exclusively correlated with tumor volume and stage as well as serum vascular endothelial growth factor levels. Conclusions The von Willebrand factor: Ag/ADAMTS13:AC ratio can potentially serve as a novel biomarker for early diagnosis of HCC in cirrhotic patients.http://link.springer.com/article/10.1186/s12876-019-1082-1ADAMTS13VWFBiomarkerHCCEarly diagnosis |
| spellingShingle | Hiroaki Takaya Tadashi Namisaki Mitsuteru Kitade Kosuke Kaji Keisuke Nakanishi Yuki Tsuji Naotaka Shimozato Kei Moriya Kenichiro Seki Yasuhiko Sawada Soichiro Saikawa Shinya Sato Hideto Kawaratani Takemi Akahane Ryuichi Noguchi Masanori Matsumoto Hitoshi Yoshiji VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma BMC Gastroenterology ADAMTS13 VWF Biomarker HCC Early diagnosis |
| title | VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| title_full | VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| title_fullStr | VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| title_full_unstemmed | VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| title_short | VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| title_sort | vwf adamts13 ratio as a potential biomarker for early detection of hepatocellular carcinoma |
| topic | ADAMTS13 VWF Biomarker HCC Early diagnosis |
| url | http://link.springer.com/article/10.1186/s12876-019-1082-1 |
| work_keys_str_mv | AT hiroakitakaya vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT tadashinamisaki vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT mitsuterukitade vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT kosukekaji vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT keisukenakanishi vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT yukitsuji vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT naotakashimozato vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT keimoriya vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT kenichiroseki vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT yasuhikosawada vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT soichirosaikawa vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT shinyasato vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT hidetokawaratani vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT takemiakahane vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT ryuichinoguchi vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT masanorimatsumoto vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma AT hitoshiyoshiji vwfadamts13ratioasapotentialbiomarkerforearlydetectionofhepatocellularcarcinoma |