Discovery of Highly Functionalized 5-hydroxy-2<i>H</i>-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen

Discovery of Highly Functionalized 5-hydroxy-2<i>H</i>-pyrrol-2-ones That Exhibit Antiestrogenic Effects in Breast and Endometrial Cancer Cells and Potentiate the Antitumoral Effect of Tamoxifen

Tamoxifen improves the overall survival rate in hormone receptor-positive breast cancer patients. However, despite the fact that it exerts antagonistic effects on the ERα, it can act as a partial agonist, resulting in tumor growth in estrogen-sensitive tissues. In this study, highly functionalized 5...

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Bibliographic Details
Main Authors: Miguel Guerra-Rodríguez, Priscila López-Rojas, Ángel Amesty, Haidée Aranda-Tavío, Yeray Brito-Casillas, Ana Estévez-Braun, Leandro Fernández-Pérez, Borja Guerra, Carlota Recio
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
5-hydroxy-2<i>H</i>-pyrrol-2-ones
ER
antiestrogen
breast cancer
endometrial cancer
synergism
Online Access:https://www.mdpi.com/2072-6694/14/21/5174

Internet

https://www.mdpi.com/2072-6694/14/21/5174

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