The gut microbiota facilitate their host tolerance to extreme temperatures
Abstract Background Exposure to extreme cold or heat temperature is one leading cause of weather-associated mortality and morbidity in animals. Emerging studies demonstrate that the microbiota residing in guts act as an integral factor required to modulate host tolerance to cold or heat exposure, bu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12866-024-03277-6 |
| _version_ | 1797199584269697024 |
|---|---|
| author | Ziguang Wang Yujie Wu Xinxin Li Xiaowen Ji Wei Liu |
| author_facet | Ziguang Wang Yujie Wu Xinxin Li Xiaowen Ji Wei Liu |
| author_sort | Ziguang Wang |
| collection | DOAJ |
| description | Abstract Background Exposure to extreme cold or heat temperature is one leading cause of weather-associated mortality and morbidity in animals. Emerging studies demonstrate that the microbiota residing in guts act as an integral factor required to modulate host tolerance to cold or heat exposure, but common and unique patterns of animal-temperature associations between cold and heat have not been simultaneously examined. Therefore, we attempted to investigate the roles of gut microbiota in modulating tolerance to cold or heat exposure in mice. Results The results showed that both cold and heat acutely change the body temperature of mice, but mice efficiently maintain their body temperature at conditions of chronic extreme temperatures. Mice adapt to extreme temperatures by adjusting body weight gain, food intake and energy harvest. Fascinatingly, 16 S rRNA sequencing shows that extreme temperatures result in a differential shift in the gut microbiota. Moreover, transplantation of the extreme-temperature microbiota is sufficient to enhance host tolerance to cold and heat, respectively. Metagenomic sequencing shows that the microbiota assists their hosts in resisting extreme temperatures through regulating the host insulin pathway. Conclusions Our findings highlight that the microbiota is a key factor orchestrating the overall energy homeostasis under extreme temperatures, providing an insight into the interaction and coevolution of hosts and gut microbiota. |
| first_indexed | 2024-04-24T07:18:04Z |
| format | Article |
| id | doaj.art-03a79474ba1e4716ae8bc6971b5116fc |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-04-24T07:18:04Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-03a79474ba1e4716ae8bc6971b5116fc2024-04-21T11:10:45ZengBMCBMC Microbiology1471-21802024-04-0124111410.1186/s12866-024-03277-6The gut microbiota facilitate their host tolerance to extreme temperaturesZiguang Wang0Yujie Wu1Xinxin Li2Xiaowen Ji3Wei Liu4School of Plant Protection, Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, Anhui Agricultural UniversitySchool of Plant Protection, Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, Anhui Agricultural UniversityChina-Japan Union Hospital, Jilin UniversitySchool of Plant Protection, Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, Anhui Agricultural UniversitySchool of Plant Protection, Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, Anhui Agricultural UniversityAbstract Background Exposure to extreme cold or heat temperature is one leading cause of weather-associated mortality and morbidity in animals. Emerging studies demonstrate that the microbiota residing in guts act as an integral factor required to modulate host tolerance to cold or heat exposure, but common and unique patterns of animal-temperature associations between cold and heat have not been simultaneously examined. Therefore, we attempted to investigate the roles of gut microbiota in modulating tolerance to cold or heat exposure in mice. Results The results showed that both cold and heat acutely change the body temperature of mice, but mice efficiently maintain their body temperature at conditions of chronic extreme temperatures. Mice adapt to extreme temperatures by adjusting body weight gain, food intake and energy harvest. Fascinatingly, 16 S rRNA sequencing shows that extreme temperatures result in a differential shift in the gut microbiota. Moreover, transplantation of the extreme-temperature microbiota is sufficient to enhance host tolerance to cold and heat, respectively. Metagenomic sequencing shows that the microbiota assists their hosts in resisting extreme temperatures through regulating the host insulin pathway. Conclusions Our findings highlight that the microbiota is a key factor orchestrating the overall energy homeostasis under extreme temperatures, providing an insight into the interaction and coevolution of hosts and gut microbiota.https://doi.org/10.1186/s12866-024-03277-6Gut microbiotaExtreme temperaturesToleranceInsulin pathwayCarbohydrate metabolism |
| spellingShingle | Ziguang Wang Yujie Wu Xinxin Li Xiaowen Ji Wei Liu The gut microbiota facilitate their host tolerance to extreme temperatures BMC Microbiology Gut microbiota Extreme temperatures Tolerance Insulin pathway Carbohydrate metabolism |
| title | The gut microbiota facilitate their host tolerance to extreme temperatures |
| title_full | The gut microbiota facilitate their host tolerance to extreme temperatures |
| title_fullStr | The gut microbiota facilitate their host tolerance to extreme temperatures |
| title_full_unstemmed | The gut microbiota facilitate their host tolerance to extreme temperatures |
| title_short | The gut microbiota facilitate their host tolerance to extreme temperatures |
| title_sort | gut microbiota facilitate their host tolerance to extreme temperatures |
| topic | Gut microbiota Extreme temperatures Tolerance Insulin pathway Carbohydrate metabolism |
| url | https://doi.org/10.1186/s12866-024-03277-6 |
| work_keys_str_mv | AT ziguangwang thegutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT yujiewu thegutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT xinxinli thegutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT xiaowenji thegutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT weiliu thegutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT ziguangwang gutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT yujiewu gutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT xinxinli gutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT xiaowenji gutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures AT weiliu gutmicrobiotafacilitatetheirhosttolerancetoextremetemperatures |