Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation
Two different procedures for inoculation of HSV on corneas of BALB/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortality than those of first grou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400004&lng=en&tlng=en |
| _version_ | 1818526905549193216 |
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| author | Sílvia Regina Ferreira Gonçalves Pereira Maria Angélica A. M. Guimarães Leonardo V. Neto Daniel Segenreich Rafael Brandão Varella Vera Lucia Antunes Chagas Fernando Portela Câmara |
| author_facet | Sílvia Regina Ferreira Gonçalves Pereira Maria Angélica A. M. Guimarães Leonardo V. Neto Daniel Segenreich Rafael Brandão Varella Vera Lucia Antunes Chagas Fernando Portela Câmara |
| author_sort | Sílvia Regina Ferreira Gonçalves Pereira |
| collection | DOAJ |
| description | Two different procedures for inoculation of HSV on corneas of BALB/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortality than those of first group, suggesting that inoculation of HSV without scarification of the cornea should be the method of choice for the study of HSV ophthalmic infection. This model showed also be an efficient experimental system to testing antiviral drugs. |
| first_indexed | 2024-12-11T06:29:17Z |
| format | Article |
| id | doaj.art-03a7cef6ca4f483cb31cb68c4b29aa8f |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-11T06:29:17Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-03a7cef6ca4f483cb31cb68c4b29aa8f2022-12-22T01:17:35ZengElsevierBrazilian Journal of Infectious Diseases1678-43915418319110.1590/S1413-86702001000400004S1413-86702001000400004Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculationSílvia Regina Ferreira Gonçalves PereiraMaria Angélica A. M. GuimarãesLeonardo V. NetoDaniel SegenreichRafael Brandão VarellaVera Lucia Antunes ChagasFernando Portela CâmaraTwo different procedures for inoculation of HSV on corneas of BALB/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortality than those of first group, suggesting that inoculation of HSV without scarification of the cornea should be the method of choice for the study of HSV ophthalmic infection. This model showed also be an efficient experimental system to testing antiviral drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400004&lng=en&tlng=enHerpes simplex virusophthalmic diseasenon-traumatic and traumatic inoculationmurine model |
| spellingShingle | Sílvia Regina Ferreira Gonçalves Pereira Maria Angélica A. M. Guimarães Leonardo V. Neto Daniel Segenreich Rafael Brandão Varella Vera Lucia Antunes Chagas Fernando Portela Câmara Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation Brazilian Journal of Infectious Diseases Herpes simplex virus ophthalmic disease non-traumatic and traumatic inoculation murine model |
| title | Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| title_full | Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| title_fullStr | Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| title_full_unstemmed | Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| title_short | Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| title_sort | herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation |
| topic | Herpes simplex virus ophthalmic disease non-traumatic and traumatic inoculation murine model |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400004&lng=en&tlng=en |
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