Multiple Functions of ATG8 Family Proteins in Plant Autophagy
Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos. A set of autophagy-related (ATG) proteins participate in various stages of the autophagic process. Among ATGs, ubiquitin-like protein ATG8 plays a ce...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-06-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00466/full |
| _version_ | 1818517106019270656 |
|---|---|
| author | Fan Bu Mingkang Yang Xu Guo Wei Huang Wei Huang Liang Chen Liang Chen |
| author_facet | Fan Bu Mingkang Yang Xu Guo Wei Huang Wei Huang Liang Chen Liang Chen |
| author_sort | Fan Bu |
| collection | DOAJ |
| description | Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos. A set of autophagy-related (ATG) proteins participate in various stages of the autophagic process. Among ATGs, ubiquitin-like protein ATG8 plays a central role in autophagy. The ATG8 protein is conjugated to the membrane lipid phosphatidylethanolamine in a ubiquitin-like conjugation reaction that is essential for autophagosome formation. In addition, ATG8 interacts with various adaptor/receptor proteins to recruit specific cargos for degradation by selective autophagy. The ATG8-interacting proteins usually contain the ATG8-interacting motif (AIM) or the ubiquitin-interacting motif (UIM) for ATG8 binding. Unlike a single ATG8 gene in yeast, multiple ATG8 orthologs have been identified in the plant kingdom. The large diversity within the ATG8 family may explain the various functions of selective autophagy in plants. Here, we discuss and summarize the current view of the structure and function of ATG8 proteins in plants. |
| first_indexed | 2024-12-11T00:51:44Z |
| format | Article |
| id | doaj.art-03a99d7a2dd540fd8add43316446b7be |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T00:51:44Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-03a99d7a2dd540fd8add43316446b7be2022-12-22T01:26:36ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-06-01810.3389/fcell.2020.00466532931Multiple Functions of ATG8 Family Proteins in Plant AutophagyFan Bu0Mingkang Yang1Xu Guo2Wei Huang3Wei Huang4Liang Chen5Liang Chen6State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, ChinaAutophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos. A set of autophagy-related (ATG) proteins participate in various stages of the autophagic process. Among ATGs, ubiquitin-like protein ATG8 plays a central role in autophagy. The ATG8 protein is conjugated to the membrane lipid phosphatidylethanolamine in a ubiquitin-like conjugation reaction that is essential for autophagosome formation. In addition, ATG8 interacts with various adaptor/receptor proteins to recruit specific cargos for degradation by selective autophagy. The ATG8-interacting proteins usually contain the ATG8-interacting motif (AIM) or the ubiquitin-interacting motif (UIM) for ATG8 binding. Unlike a single ATG8 gene in yeast, multiple ATG8 orthologs have been identified in the plant kingdom. The large diversity within the ATG8 family may explain the various functions of selective autophagy in plants. Here, we discuss and summarize the current view of the structure and function of ATG8 proteins in plants.https://www.frontiersin.org/article/10.3389/fcell.2020.00466/fullautophagyATG8cargo receptorsselective autophagyAIMUIM |
| spellingShingle | Fan Bu Mingkang Yang Xu Guo Wei Huang Wei Huang Liang Chen Liang Chen Multiple Functions of ATG8 Family Proteins in Plant Autophagy Frontiers in Cell and Developmental Biology autophagy ATG8 cargo receptors selective autophagy AIM UIM |
| title | Multiple Functions of ATG8 Family Proteins in Plant Autophagy |
| title_full | Multiple Functions of ATG8 Family Proteins in Plant Autophagy |
| title_fullStr | Multiple Functions of ATG8 Family Proteins in Plant Autophagy |
| title_full_unstemmed | Multiple Functions of ATG8 Family Proteins in Plant Autophagy |
| title_short | Multiple Functions of ATG8 Family Proteins in Plant Autophagy |
| title_sort | multiple functions of atg8 family proteins in plant autophagy |
| topic | autophagy ATG8 cargo receptors selective autophagy AIM UIM |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00466/full |
| work_keys_str_mv | AT fanbu multiplefunctionsofatg8familyproteinsinplantautophagy AT mingkangyang multiplefunctionsofatg8familyproteinsinplantautophagy AT xuguo multiplefunctionsofatg8familyproteinsinplantautophagy AT weihuang multiplefunctionsofatg8familyproteinsinplantautophagy AT weihuang multiplefunctionsofatg8familyproteinsinplantautophagy AT liangchen multiplefunctionsofatg8familyproteinsinplantautophagy AT liangchen multiplefunctionsofatg8familyproteinsinplantautophagy |