Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study
Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/6/476 |
| _version_ | 1827715685986336768 |
|---|---|
| author | Bernardo U. Peres AJ Hirsch Allen Aditi Shah Nurit Fox Ismail Laher Fernanda Almeida Rachel Jen Najib Ayas |
| author_facet | Bernardo U. Peres AJ Hirsch Allen Aditi Shah Nurit Fox Ismail Laher Fernanda Almeida Rachel Jen Najib Ayas |
| author_sort | Bernardo U. Peres |
| collection | DOAJ |
| description | Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m<sup>2)</sup>. In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (<i>p</i> = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (<i>p</i> < 0.0001) and no previous history of cardiovascular disease (<i>p</i> = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA. |
| first_indexed | 2024-03-10T19:25:35Z |
| format | Article |
| id | doaj.art-03ab45196c66403cbda8373ea0a4badc |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T19:25:35Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-03ab45196c66403cbda8373ea0a4badc2023-11-20T02:36:07ZengMDPI AGAntioxidants2076-39212020-06-019647610.3390/antiox9060476Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional StudyBernardo U. Peres0AJ Hirsch Allen1Aditi Shah2Nurit Fox3Ismail Laher4Fernanda Almeida5Rachel Jen6Najib Ayas7Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDepartment of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2A1, CanadaDepartment of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, CanadaOxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m<sup>2)</sup>. In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (<i>p</i> = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (<i>p</i> < 0.0001) and no previous history of cardiovascular disease (<i>p</i> = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA.https://www.mdpi.com/2076-3921/9/6/476obstructive sleep apnea (OSA)biomarkersoxidative stress |
| spellingShingle | Bernardo U. Peres AJ Hirsch Allen Aditi Shah Nurit Fox Ismail Laher Fernanda Almeida Rachel Jen Najib Ayas Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study Antioxidants obstructive sleep apnea (OSA) biomarkers oxidative stress |
| title | Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study |
| title_full | Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study |
| title_fullStr | Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study |
| title_full_unstemmed | Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study |
| title_short | Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study |
| title_sort | obstructive sleep apnea and circulating biomarkers of oxidative stress a cross sectional study |
| topic | obstructive sleep apnea (OSA) biomarkers oxidative stress |
| url | https://www.mdpi.com/2076-3921/9/6/476 |
| work_keys_str_mv | AT bernardouperes obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT ajhirschallen obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT aditishah obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT nuritfox obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT ismaillaher obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT fernandaalmeida obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT racheljen obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy AT najibayas obstructivesleepapneaandcirculatingbiomarkersofoxidativestressacrosssectionalstudy |