Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent
Background: The aim of the present study was to formulate and evaluate the herbal gels containing Chinese Eucalyptus Oil or Eucalyptus globulus Labill. (E. globulus) using different polymers (Methylcellulose, HPMC, Carbopol-940) and checked their antimicrobial effects against different microorganism...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142523001197 |
| _version_ | 1797388587784732672 |
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| author | Deepshikha Dubey Vibha Yogesh Murti Pranay Wal Akash Ved Parshant Kumar Anuj Kumar Sharma Harinath Dwivedi Anita Singh Manjul Pratap Singh Mayank Kulshreshtha |
| author_facet | Deepshikha Dubey Vibha Yogesh Murti Pranay Wal Akash Ved Parshant Kumar Anuj Kumar Sharma Harinath Dwivedi Anita Singh Manjul Pratap Singh Mayank Kulshreshtha |
| author_sort | Deepshikha Dubey |
| collection | DOAJ |
| description | Background: The aim of the present study was to formulate and evaluate the herbal gels containing Chinese Eucalyptus Oil or Eucalyptus globulus Labill. (E. globulus) using different polymers (Methylcellulose, HPMC, Carbopol-940) and checked their antimicrobial effects against different microorganisms. the oil from Eucalyptus globulus has a good medicinal value in the Chinese medicine system. Methods: A topical gels formulation were designed by using mentioned oil with polymers, as well as gelling agent with different excipients. Microbial species, such as Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Aspergillus tubingensis (A. tubingensis) have been selected for the study. Results: The gel's physical properties complied with the necessary standards. These four gel compositions efficiently stop some strains' development. Studies show that the gel was also particularly effective against gram-negative and fungal bacteria. The Zones of inhibition (ZOI) were found between 1.2 and 10.2 µm. The formulation F4 have good antifungal potential. Conclusion: The herbal gel was found to have highly promising anti-fungal and anti-fungal activity against many skin-related infections in a concentration-dependant manner but further research must be needed. |
| first_indexed | 2024-03-08T22:42:55Z |
| format | Article |
| id | doaj.art-03abec9226ae400b82769a5891fc36d3 |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-03-08T22:42:55Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-03abec9226ae400b82769a5891fc36d32023-12-17T06:43:02ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252023-12-019100333Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agentDeepshikha Dubey0 Vibha1Yogesh Murti2Pranay Wal3Akash Ved4Parshant Kumar5Anuj Kumar Sharma6Harinath Dwivedi7Anita Singh8Manjul Pratap Singh9Mayank Kulshreshtha10Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh IndiaDepartment of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh IndiaInstitute of Pharmaceutical Research, GLA University, Mathura, IndiaPranveer Singh Institute of Technology, Kanpur, IndiaFaculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Lucknow, Uttar Pradesh, IndiaDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh IndiaDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh IndiaSchool of Pharmacy, Babu Banarasi Das University, Lucknow, Uttar Pradesh, IndiaSundeep Pharmacy College, Ghaziabad, IndiaABESIT Collage of Pharmacy, Ghaziabad U.P., IndiaDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh India; Corresponding author.Background: The aim of the present study was to formulate and evaluate the herbal gels containing Chinese Eucalyptus Oil or Eucalyptus globulus Labill. (E. globulus) using different polymers (Methylcellulose, HPMC, Carbopol-940) and checked their antimicrobial effects against different microorganisms. the oil from Eucalyptus globulus has a good medicinal value in the Chinese medicine system. Methods: A topical gels formulation were designed by using mentioned oil with polymers, as well as gelling agent with different excipients. Microbial species, such as Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Aspergillus tubingensis (A. tubingensis) have been selected for the study. Results: The gel's physical properties complied with the necessary standards. These four gel compositions efficiently stop some strains' development. Studies show that the gel was also particularly effective against gram-negative and fungal bacteria. The Zones of inhibition (ZOI) were found between 1.2 and 10.2 µm. The formulation F4 have good antifungal potential. Conclusion: The herbal gel was found to have highly promising anti-fungal and anti-fungal activity against many skin-related infections in a concentration-dependant manner but further research must be needed.http://www.sciencedirect.com/science/article/pii/S2667142523001197Chinese eucalyptus oilMethylcelluloseHPMCCarbopol-940Herbal gel |
| spellingShingle | Deepshikha Dubey Vibha Yogesh Murti Pranay Wal Akash Ved Parshant Kumar Anuj Kumar Sharma Harinath Dwivedi Anita Singh Manjul Pratap Singh Mayank Kulshreshtha Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent Pharmacological Research - Modern Chinese Medicine Chinese eucalyptus oil Methylcellulose HPMC Carbopol-940 Herbal gel |
| title | Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| title_full | Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| title_fullStr | Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| title_full_unstemmed | Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| title_short | Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| title_sort | formulation and evaluation of chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent |
| topic | Chinese eucalyptus oil Methylcellulose HPMC Carbopol-940 Herbal gel |
| url | http://www.sciencedirect.com/science/article/pii/S2667142523001197 |
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